UniProt Q8NCE0
tRNA-splicing endonuclease subunit Sen2 (Q8NCE0)
tRNA-splicing endonuclease subunit Sen2 (UniProt Q8NCE0), EC 4.6.1.16: 3 experimental structures and 1 predicted model on GenesisL1, 33 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8NCE0
- Protein
- tRNA-splicing endonuclease subunit Sen2
- EC
- 4.6.1.16
- Experimental structures
- 3
- Predicted models
- 1
- Pockets
- 33 · 4 records with a druggable one
Structures
4 records of Q8NCE0 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7UXA | Human tRNA Splicing Endonuclease Complex bound to pre-tRNA-ARG | electron microscopy | C | — | 8 (best 0.81) |
| 8HMZ | Cryo-EM structure of the human post-catalytic TSEN/pre-tRNA complex | electron microscopy | A | — | 9 (best 0.83) |
| 8ISS | Cryo-EM structure of wild-type human tRNA Splicing Endonuclease Complex bound to pre-tRNA-ARG at… | electron microscopy | B | — | 9 (best 0.81) |
| Q8NCE0 | AlphaFold monomer V2.0 prediction for tRNA-splicing endonuclease subunit SEN2 (Q8NCE0) | predicted | A | — | 7 (best 0.74) |
Experiment against prediction
- 8ISS chain B against the predicted model Q8NCE0: TM-score 0.97, RMSD 1.10 Å
- 7UXA chain C against the predicted model Q8NCE0: TM-score 0.96, RMSD 1.33 Å
- 8HMZ chain A against the predicted model Q8NCE0: TM-score 0.85, RMSD 2.81 Å
Elsewhere
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