UniProt Q8NCC3
Group XV phospholipase A2 (Q8NCC3)
Group XV phospholipase A2 (UniProt Q8NCC3), EC 2.3.1.-: 14 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8NCC3
- Protein
- Group XV phospholipase A2
- EC
- 2.3.1.-
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 20 · 3 records with a druggable one
Structures
15 records of Q8NCC3 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4X90 | Crystal structure of lysosomal phospholipase A2 | x-ray diffraction | A, B, C, D | — | — |
| 4X91 | Crystal structure of lysosomal phospholipase A2 in complex with isopropyl… | x-ray diffraction | A, B, C, D | — | — |
| 4X92 | Crystal structure of Lysosomal Phospholipase A2-S165A | x-ray diffraction | A | — | — |
| 4X92 | Crystal structure of lysosomal phospholipase A2-S165A | x-ray diffraction | A | — | — |
| 4X93 | Crystal structure of Lysosomal Phospholipase A2 crystallized in the presence of methyl arachidonyl… | x-ray diffraction | A, B | — | — |
| 4X93 | Crystal structure of lysosomal phospholipase A2 crystallized in the presence of methyl arachidonyl… | x-ray diffraction | A, B | — | — |
| 4X94 | Crystal structure of Lysosomal Phospholipase A2 crystallized in the presence of methyl arachidonyl… | x-ray diffraction | A | — | — |
| 4X94 | Crystal structure of lysosomal phospholipase A2 crystallized in the presence of methyl arachidonyl… | x-ray diffraction | A | — | — |
| 4X95 | Crystal structure of fully glycosylated Lysosomal Phospholipase A2 in complex with methyl… | x-ray diffraction | A, B | — | — |
| 4X95 | Crystal structure of fully glycosylated lysosomal phospholipase A2 in complex with methyl… | x-ray diffraction | A, B | — | — |
| 4X97 | Crystal structure of Lysosomal Phospholipase A2 in complex with methyl arachidonyl… | x-ray diffraction | A, B, C, D | NAG, MAY, PO4, CL | 13 (best 0.79) |
| 4X97 | Crystal structure of lysosomal phospholipase A2 in complex with methyl arachidonyl… | x-ray diffraction | A, B, C, D | — | — |
| 6MTW | Lysosomal Phospholipase A2 in complex with Zinc | x-ray diffraction | A, B | NAG, CL, ZN | 6 (best 0.78) |
| 6MTW | Lysosomal phospholipase A2 in complex with zinc | x-ray diffraction | A, B | NAG, CL, ZN | — |
| Q8NCC3 | AlphaFold monomer V2.0 prediction for phospholipase A2 group xv (Q8NCC3) | predicted | A | — | 1 (best 0.76) |
Ligands
Experiment against prediction
- 4X97 chain A against the predicted model Q8NCC3: TM-score 1.00, RMSD 0.37 Å
- 4X97 chain A against the predicted model Q8NCC3: TM-score 1.00, RMSD 0.37 Å
- 4X92 chain A against the predicted model Q8NCC3: TM-score 1.00, RMSD 0.45 Å
- 4X92 chain A against the predicted model Q8NCC3: TM-score 1.00, RMSD 0.45 Å
- 4X97 chain C against the predicted model Q8NCC3: TM-score 1.00, RMSD 0.48 Å
- 4X97 chain C against the predicted model Q8NCC3: TM-score 1.00, RMSD 0.48 Å
- 4X90 chain A against the predicted model Q8NCC3: TM-score 0.99, RMSD 0.53 Å
- 4X94 chain A against the predicted model Q8NCC3: TM-score 0.99, RMSD 0.55 Å
- 4X94 chain A against the predicted model Q8NCC3: TM-score 0.99, RMSD 0.55 Å
- 4X91 chain A against the predicted model Q8NCC3: TM-score 0.99, RMSD 0.54 Å
Elsewhere
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