UniProt Q8K3I6
Interleukin-27 subunit alpha (Q8K3I6)
Interleukin-27 subunit alpha (UniProt Q8K3I6): 3 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 25 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8K3I6
- Protein
- Interleukin-27 subunit alpha
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 25 · 3 records with a druggable one
Structures
4 records of Q8K3I6 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7Z0L | IL-27 signalling complex | electron microscopy | B | NAG | 9 (best 0.68) |
| 7Z0L | Il-27 signalling complex | electron microscopy | B | NAG | 9 (best 0.68) |
| 7ZG0 | Murine IL-27 in complex with IL-27Ra and a non-competing Nb | x-ray diffraction | A, B | NAG | 7 (best 0.83) |
| Q8K3I6 | AlphaFold monomer V2.0 prediction for interleukin-27 subunit alpha (Q8K3I6) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 3 records
Experiment against prediction
- 7ZG0 chain A against the predicted model Q8K3I6: TM-score 0.96, RMSD 1.03 Å
- 7ZG0 chain B against the predicted model Q8K3I6: TM-score 0.96, RMSD 1.07 Å
- 7Z0L chain B against the predicted model Q8K3I6: TM-score 0.48, RMSD 0.77 Å
- 7Z0L chain B against the predicted model Q8K3I6: TM-score 0.48, RMSD 0.77 Å
- 7Z0L chain B against the predicted model O35228: TM-score 0.45, RMSD 2.70 Å
- 7Z0L chain B against the predicted model O35228: TM-score 0.45, RMSD 2.70 Å
Elsewhere
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