UniProt Q8IZY2
Phospholipid-transporting ATPase ABCA7 (Q8IZY2)
Phospholipid-transporting ATPase ABCA7 (UniProt Q8IZY2), EC 7.6.2.1: 4 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 80 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8IZY2
- Protein
- Phospholipid-transporting ATPase ABCA7
- EC
- 7.6.2.1
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 80 · 4 records with a druggable one
Structures
5 records of Q8IZY2 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8EDW | Cryo-EM Structure of human ABCA7 in BPL/Ch Nanodiscs | electron microscopy | A | NAG, UNL, AGS | 20 (best 0.83) |
| 8EE6 | Cryo-EM Structure of human ABCA7 in PE/Ch nanodiscs | electron microscopy | A | NAG, BMA, UNL, AGS | 20 (best 0.82) |
| 8EEB | Cryo-EM structure of human ABCA7 in Digitonin | electron microscopy | A | NAG | 20 (best 0.85) |
| 8EOP | Cryo-EM Structure of Nanodisc reconstituted human ABCA7 EQ mutant in ATP bound closed state | electron microscopy | A | NAG, BMA, ATP, MG | 20 (best 0.84) |
| Q8IZY2 | AlphaFold monomer V2.0 prediction for phospholipid-transporting ATPase ABCA7 (Q8IZY2) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8EEB chain A against the predicted model Q8IZY2: TM-score 0.93, RMSD 3.85 Å
- 8EDW chain A against the predicted model Q8IZY2: TM-score 0.88, RMSD 5.17 Å
- 8EE6 chain A against the predicted model Q8IZY2: TM-score 0.87, RMSD 5.22 Å
- 8EOP chain A against the predicted model Q8IZY2: TM-score 0.76, RMSD 6.90 Å
Elsewhere
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