UniProt Q8IYU2
E3 ubiquitin-protein ligase HACE1 (Q8IYU2)
E3 ubiquitin-protein ligase HACE1 (UniProt Q8IYU2), EC 2.3.2.26: 4 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 80 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q8IYU2
- Protein
- E3 ubiquitin-protein ligase HACE1
- EC
- 2.3.2.26
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 80 · 5 records with a druggable one
Structures
5 records of Q8IYU2 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8H8X | Cryo-EM structure of HACE1 monomer | electron microscopy | A | — | 14 (best 0.75) |
| 8HAE | Cryo-EM structure of HACE1 dimer | electron microscopy | A, B | — | 20 (best 0.83) |
| 8PWL | Cryo-EM structure of a full-length HACE1 dimer | electron microscopy | A, B | — | 20 (best 0.85) |
| 8Q0N | HACE1 in complex with RAC1 Q61L | electron microscopy | B | 04E | 15 (best 0.77) |
| Q8IYU2 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase HACE1 (Q8IYU2) | predicted | A | — | 11 (best 0.71) |
Ligands
- 04E · iodoacetic acid · in 1 record
Experiment against prediction
- 8PWL chain B against the predicted model Q8IYU2: TM-score 0.81, RMSD 4.53 Å
- 8PWL chain A against the predicted model Q8IYU2: TM-score 0.78, RMSD 5.35 Å
- 8HAE chain A against the predicted model Q8IYU2: TM-score 0.78, RMSD 5.35 Å
- 8Q0N chain B against the predicted model Q8IYU2: TM-score 0.77, RMSD 3.71 Å
- 8H8X chain A against the predicted model Q8IYU2: TM-score 0.75, RMSD 5.91 Å
Elsewhere
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