UniProt Q8IY47
Kelch repeat and BTB domain-containing protein 2 (Q8IY47)
Kelch repeat and BTB domain-containing protein 2 (UniProt Q8IY47): 10 experimental structures and 1 predicted model on GenesisL1, 83 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8IY47
- Protein
- Kelch repeat and BTB domain-containing protein 2
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 83 · 10 records with a druggable one
Structures
11 records of Q8IY47 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8GQ6 | Cryo-EM Structure of the KBTBD2-CUL3-Rbx1 dimeric complex | electron microscopy | A, B | — | 10 (best 0.77) |
| 8H33 | Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 tetrameric complex | electron microscopy | A, B, G, J | — | 8 (best 0.82) |
| 8H34 | Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 hexameric complex | electron microscopy | P, N, A, B, G, J | — | 9 (best 0.82) |
| 8H35 | Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 octameric complex | electron microscopy | A, B, G, J, P, N, S, U | — | 9 (best 0.80) |
| 8H36 | Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a dimeric complex | electron microscopy | A, B | — | 9 (best 0.79) |
| 8H37 | Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a tetrameric complex | electron microscopy | A, B, N, P | — | 8 (best 0.84) |
| 8H38 | Cryo-EM Structure of the KBTBD2-CRL3~N8-CSN(mutate) complex | electron microscopy | I, M | — | 7 (best 0.79) |
| 8H3A | Cryo-EM Structure of the KBTBD2-CRL3~N8(removed)-CSN complex | electron microscopy | I, M | — | 7 (best 0.79) |
| 8H3F | Cryo-EM Structure of the KBTBD2-CRL3-CSN complex | electron microscopy | I, M | — | 7 (best 0.79) |
| 8H3R | Cryo-EM Structure of the KBTBD2-CRL3~N8 dimeric complex | electron microscopy | A, B | — | 9 (best 0.77) |
| Q8IY47 | AlphaFold monomer V2.0 prediction for kelch repeat and btb domain- containing protein 2 (Q8IY47) | predicted | A | — | — |
Experiment against prediction
- 8H34 chain B against the predicted model Q8IY47: TM-score 0.96, RMSD 1.57 Å
- 8H35 chain U against the predicted model Q8IY47: TM-score 0.96, RMSD 1.57 Å
- 8GQ6 chain B against the predicted model Q8IY47: TM-score 0.96, RMSD 1.58 Å
- 8H34 chain N against the predicted model Q8IY47: TM-score 0.96, RMSD 1.58 Å
- 8H35 chain J against the predicted model Q8IY47: TM-score 0.96, RMSD 1.58 Å
- 8H35 chain N against the predicted model Q8IY47: TM-score 0.96, RMSD 1.58 Å
- 8H34 chain J against the predicted model Q8IY47: TM-score 0.96, RMSD 1.59 Å
- 8H35 chain B against the predicted model Q8IY47: TM-score 0.96, RMSD 1.60 Å
- 8H38 chain M against the predicted model Q8IY47: TM-score 0.95, RMSD 1.82 Å
- 8H3R chain B against the predicted model Q8IY47: TM-score 0.95, RMSD 1.83 Å
Elsewhere
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