UniProt Q8IXH7
Negative elongation factor C/D (Q8IXH7)
Negative elongation factor C/D (UniProt Q8IXH7): 12 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 26 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8IXH7
- Protein
- Negative elongation factor C/D
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 26 · 8 records with a druggable one
Structures
13 records of Q8IXH7 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5L3X | Crystal structure of negative elongation factor subcomplex NELF-AC | x-ray diffraction | B | CL | — |
| 5L3X | Crystal structure of negative elongation factor subcomplex nelf-ac | x-ray diffraction | B | CL | — |
| 6GML | Structure of paused transcription complex pol II-dsif-nelf | electron microscopy | W | — | — |
| 7PKS | Structural basis of Integrator-mediated transcription regulation | electron microscopy | W | — | — |
| 7YCX | The structure of INTAC-PEC complex | electron microscopy | g | — | 1 (best 0.79) |
| 8RBX | Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex | electron microscopy | w | — | — |
| 8UHA | Structure of paused transcription complex Pol II-DSIF-NELF - tilted | electron microscopy | W | — | 3 (best 0.74) |
| 8UHD | Structure of paused transcription complex Pol II-DSIF-NELF - post-translocated | electron microscopy | W | — | 3 (best 0.75) |
| 8UHG | Structure of paused transcription complex Pol II-DSIF-NELF - poised post-translocated | electron microscopy | W | — | 3 (best 0.78) |
| 8UI0 | Structure of poised transcription complex Pol II-DSIF-NELF - pre-translocated | electron microscopy | W | — | 3 (best 0.78) |
| 8UIS | Structure of transcription complex Pol II-DSIF-NELF-TFIIS | electron microscopy | W | — | 3 (best 0.78) |
| 8W8E | human co-transcriptional RNA capping enzyme RNGTT | electron microscopy | W | — | 3 (best 0.83) |
| Q8IXH7 | AlphaFold monomer V2.0 prediction for negative elongation factor C/D (Q8IXH7) | predicted | A | — | 7 (best 0.70) |
Ligands
- CL · Chloride ion · in 2 records
Experiment against prediction
- 8UIS chain W against the predicted model Q8IXH7: TM-score 0.97, RMSD 1.29 Å
- 5L3X chain B against the predicted model Q8IXH7: TM-score 0.97, RMSD 1.47 Å
- 5L3X chain B against the predicted model Q8IXH7: TM-score 0.97, RMSD 1.47 Å
- 7PKS chain W against the predicted model Q8IXH7: TM-score 0.95, RMSD 2.04 Å
- 8UHA chain W against the predicted model Q8IXH7: TM-score 0.94, RMSD 2.22 Å
- 8W8E chain W against the predicted model Q8IXH7: TM-score 0.94, RMSD 2.29 Å
- 8RBX chain w against the predicted model Q8IXH7: TM-score 0.93, RMSD 2.38 Å
- 6GML chain W against the predicted model Q8IXH7: TM-score 0.92, RMSD 2.75 Å
- 7YCX chain g against the predicted model Q8IXH7: TM-score 0.91, RMSD 2.79 Å
- 8UHD chain W against the predicted model Q8IXH7: TM-score 0.91, RMSD 2.84 Å
Elsewhere
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