UniProt Q8IWV7
E3 ubiquitin-protein ligase UBR1 (Q8IWV7)
E3 ubiquitin-protein ligase UBR1 (UniProt Q8IWV7), EC 6.3.2.-, 6.3.2.19: 4 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8IWV7
- Protein
- E3 ubiquitin-protein ligase UBR1
- EC
- 6.3.2.-, 6.3.2.19
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 21 · 1 record with a druggable one
Structures
5 records of Q8IWV7 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3NY1 | Structure of the ubr-box of the UBR1 ubiquitin ligase | x-ray diffraction | A, B | ZN | 1 (best 0.46) |
| 3NY1 | Structure of the ubr-box of the UBR1 ubiquitin ligase | x-ray diffraction | A, B | — | — |
| 5TDC | Crystal structure of the human UBR-box domain from UBR1 in complex with monomethylated arginine… | x-ray diffraction | A, C | ZN, SO4 | — |
| 5TDC | Crystal structure of the human ubr-box domain from UBR1 in complex with monomethylated arginine… | x-ray diffraction | A, C | ZN, SO4 | — |
| Q8IWV7 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase UBR1 (Q8IWV7) | predicted | A | — | 20 (best 0.75) |
Ligands
Experiment against prediction
- 5TDC chain A against the predicted model Q8IWV7: TM-score 0.98, RMSD 0.46 Å
- 5TDC chain A against the predicted model Q8IWV7: TM-score 0.98, RMSD 0.46 Å
- 3NY1 chain B against the predicted model Q8IWV7: TM-score 0.97, RMSD 0.49 Å
- 3NY1 chain B against the predicted model Q8IWV7: TM-score 0.97, RMSD 0.49 Å
- 5TDC chain C against the predicted model Q8IWV7: TM-score 0.97, RMSD 0.59 Å
- 5TDC chain C against the predicted model Q8IWV7: TM-score 0.97, RMSD 0.59 Å
- 3NY1 chain A against the predicted model Q8IWV7: TM-score 0.93, RMSD 1.02 Å
- 3NY1 chain A against the predicted model Q8IWV7: TM-score 0.93, RMSD 1.02 Å
Elsewhere
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