UniProt Q8IVW8
Sphingosine-1-phosphate transporter SPNS2 (Q8IVW8)
Sphingosine-1-phosphate transporter SPNS2 (UniProt Q8IVW8): 12 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 49 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q8IVW8
- Protein
- Sphingosine-1-phosphate transporter SPNS2
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 49 · 13 records with a druggable one
Structures
13 records of Q8IVW8 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7YUB | S1P-bound human SPNS2 | electron microscopy | R | S1P | 6 (best 0.79) |
| 7YUD | FTY720p-bound human SPNS2 | electron microscopy | R | J89 | 4 (best 0.79) |
| 7YUF | apo human SPNS2 | electron microscopy | R | — | 5 (best 0.79) |
| 8EX4 | Human S1P transporter Spns2 in an inward-facing open conformation (state 1) | electron microscopy | A | S1P | 4 (best 0.81) |
| 8EX5 | Human S1P transporter Spns2 in an outward-facing open conformation (state 4) | electron microscopy | A | — | 2 (best 0.82) |
| 8EX6 | Human S1P transporter Spns2 in an inward-facing open conformation (state 1*) | electron microscopy | A | S1P | 4 (best 0.80) |
| 8EX7 | Human S1P transporter Spns2 in an outward-facing partially occluded conformation (state 3) | electron microscopy | A | — | 2 (best 0.80) |
| 8EX8 | Human S1P transporter Spns2 in an outward-facing partially occluded conformation (state 2) | electron microscopy | A | — | 4 (best 0.81) |
| 8G92 | Structure of inhibitor 16d-bound SPNS2 | electron microscopy | A | YUX | 2 (best 0.79) |
| 8JHQ | Cryo-EM structure of human S1P transporter SPNS2 bound with S1P | electron microscopy | A | S1P | 2 (best 0.80) |
| 8JHR | Cryo-EM structure of human S1P transporter SPNS2 bound with an inhibitor 16d | electron microscopy | A | YUX | 3 (best 0.79) |
| 8KAE | 16d-bound human SPNS2 | electron microscopy | R | YUX | 6 (best 0.79) |
| Q8IVW8 | AlphaFold monomer V2.0 prediction for protein spinster homolog 2 (Q8IVW8) | predicted | A | — | 5 (best 0.84) |
Ligands
Experiment against prediction
- 8EX4 chain A against the predicted model Q8IVW8: TM-score 0.99, RMSD 0.64 Å
- 8EX6 chain A against the predicted model Q8IVW8: TM-score 0.99, RMSD 0.69 Å
- 8G92 chain A against the predicted model Q8IVW8: TM-score 0.99, RMSD 0.70 Å
- 7YUD chain R against the predicted model Q8IVW8: TM-score 0.97, RMSD 1.28 Å
- 7YUF chain R against the predicted model Q8IVW8: TM-score 0.97, RMSD 1.31 Å
- 8KAE chain R against the predicted model Q8IVW8: TM-score 0.97, RMSD 1.33 Å
- 8JHR chain A against the predicted model Q8IVW8: TM-score 0.97, RMSD 1.68 Å
- 7YUB chain R against the predicted model Q8IVW8: TM-score 0.97, RMSD 1.48 Å
- 8JHQ chain A against the predicted model Q8IVW8: TM-score 0.96, RMSD 1.72 Å
- 8EX8 chain A against the predicted model Q8IVW8: TM-score 0.84, RMSD 3.53 Å
Elsewhere
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