UniProt Q8IVH8
Mitogen-activated protein kinase kinase kinase kinase 3 (Q8IVH8)
Mitogen-activated protein kinase kinase kinase kinase 3 (UniProt Q8IVH8): 2 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 10 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8IVH8
- Protein
- Mitogen-activated protein kinase kinase kinase kinase 3
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 10 · 1 record with a druggable one
Structures
3 records of Q8IVH8 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5J5T | GLK co-crystal structure with aminopyrrolopyrimidine inhibitor | x-ray diffraction | A | 6G2 | — |
| 5J5T | Glk co-crystal structure with aminopyrrolopyrimidine inhibitor | x-ray diffraction | A | — | — |
| Q8IVH8 | AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase kinase kinase kinase 3… | predicted | A | — | 10 (best 0.76) |
Ligands
- 6G2 · 5-[2-(piperidin-4-yl)-1,3-thiazol-5-yl]-3-[(pyridin-4-yl)methoxy]pyridin-2-amine · in 1 record
Experiment against prediction
- 5J5T chain A against the predicted model Q8IVH8: TM-score 0.89, RMSD 2.05 Å
- 5J5T chain A against the predicted model Q8IVH8: TM-score 0.89, RMSD 2.05 Å
Elsewhere
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