UniProt Q8IU99
Calcium homeostasis modulator protein 1 (Q8IU99)
Calcium homeostasis modulator protein 1 (UniProt Q8IU99): 4 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 80 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8IU99
- Protein
- Calcium homeostasis modulator protein 1
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 80 · 4 records with a druggable one
Structures
5 records of Q8IU99 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8GMP | Cryo-EM structure of octameric human CALHM1 with a I109W point mutation | electron microscopy | C, A, B, D, E, F, G, H | POV | 20 (best 0.73) |
| 8GMR | Cryo-EM structure of octameric human CALHM1 | electron microscopy | B, A, C, D, E, F, G, H | POV | 20 (best 0.70) |
| 8S8Z | Cryo-EM structure of octameric human CALHM1 (I109W) in complex with ruthenium red | electron microscopy | B, A, C, D, E, F, G, H | POV | 20 (best 0.77) |
| 8S90 | Cryo-EM structure of octameric human CALHM1 (I109W) in complex with ruthenium red (C1) | electron microscopy | B, A, C, D, E, F, G, H | — | 20 (best 0.79) |
| Q8IU99 | AlphaFold monomer V2.0 prediction for calcium homeostasis modulator protein 1 (Q8IU99) | predicted | A | — | — |
Ligands
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 3 records
Experiment against prediction
- 8GMP chain G against the predicted model Q8IU99: TM-score 0.83, RMSD 2.69 Å
- 8GMP chain B against the predicted model Q8IU99: TM-score 0.83, RMSD 2.69 Å
- 8GMP chain C against the predicted model Q8IU99: TM-score 0.83, RMSD 2.69 Å
- 8GMP chain E against the predicted model Q8IU99: TM-score 0.83, RMSD 2.69 Å
- 8GMP chain D against the predicted model Q8IU99: TM-score 0.83, RMSD 2.69 Å
- 8GMP chain F against the predicted model Q8IU99: TM-score 0.83, RMSD 2.69 Å
- 8GMP chain H against the predicted model Q8IU99: TM-score 0.83, RMSD 2.69 Å
- 8GMP chain A against the predicted model Q8IU99: TM-score 0.83, RMSD 2.69 Å
- 8GMR chain G against the predicted model Q8IU99: TM-score 0.82, RMSD 2.96 Å
- 8GMR chain B against the predicted model Q8IU99: TM-score 0.82, RMSD 2.96 Å
Elsewhere
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