UniProt Q8IU85
Calcium/calmodulin-dependent protein kinase type 1D (Q8IU85)
Calcium/calmodulin-dependent protein kinase type 1D (UniProt Q8IU85), EC 2.7.11.17: 9 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 6 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q8IU85
- Protein
- Calcium/calmodulin-dependent protein kinase type 1D
- EC
- 2.7.11.17
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 6 · 4 records with a druggable one
Structures
10 records of Q8IU85 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2JC6 | Crystal structure of human calmodulin-dependent protein kinase 1D | x-ray diffraction | A, C | — | — |
| 2JC6 | Crystal structure of human calmodulin-dependent protein kinase 1D | x-ray diffraction | A, C | — | — |
| 6QP5 | Apo Human Calcium/Calmodulin-dependent kinase type 1D | x-ray diffraction | A | SO4 | — |
| 6QP5 | Apo human CALCIUM/CALMODULIN-dependent kinase type 1D | x-ray diffraction | A | SO4 | — |
| 6T28 | Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 19… | x-ray diffraction | AAA | SO4, M92 | 1 (best 0.65) |
| 6T29 | Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 18… | x-ray diffraction | AAA | SO4, M8Z | 1 (best 0.64) |
| 6T6F | Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 8… | x-ray diffraction | A, B | MMW | — |
| 8BFM | Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) in complex with FZ331 | x-ray diffraction | A | SO4, QI6 | 1 (best 0.71) |
| 8BFS | Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) in complex with FZ326 | x-ray diffraction | A | SO4, QNR | 3 (best 0.61) |
| Q8IU85 | AlphaFold monomer V2.0 prediction for CALCIUM/CALMODULIN-dependent protein kinase type 1D (Q8IU85) | predicted | A | — | — |
Ligands
- SO4 · Sulfate ion · in 6 records
- M8Z · 2-[(3~{S})-3-azanylpiperidin-1-yl]-4-[[3,5-bis(2-cyanopropan-2-yl)phenyl]amino]pyrimidine-5-carboxamide · in 1 record
- M92 · 2-[(3~{S})-3-azanylpiperidin-1-yl]-4-[[2,6-di(propan-2-yl)pyridin-4-yl]amino]pyrimidine-5-carboxamide · in 1 record
- MMW · 2-[(3~{S})-3-azanylpiperidin-1-yl]-4-[[3-(trifluoromethyl)phenyl]amino]pyrimidine-5-carboxamide · in 1 record
- QI6 · pyrazolo[5,1-a]phthalazin-6-amine · in 1 record
- QNR · 3~{H}-pyrrolo[2,3-c]isoquinolin-5-amine · in 1 record
Experiment against prediction
- 8BFM chain A against the predicted model Q8IU85: TM-score 0.96, RMSD 1.32 Å
- 6QP5 chain A against the predicted model Q8IU85: TM-score 0.95, RMSD 1.45 Å
- 6QP5 chain A against the predicted model Q8IU85: TM-score 0.95, RMSD 1.45 Å
- 8BFS chain A against the predicted model Q8IU85: TM-score 0.95, RMSD 1.48 Å
- 6T28 chain AAA against the predicted model Q8IU85: TM-score 0.94, RMSD 1.60 Å
- 6T29 chain AAA against the predicted model Q8IU85: TM-score 0.94, RMSD 1.61 Å
- 6T6F chain A against the predicted model Q8IU85: TM-score 0.93, RMSD 1.23 Å
- 2JC6 chain A against the predicted model Q8IU85: TM-score 0.93, RMSD 2.09 Å
- 2JC6 chain A against the predicted model Q8IU85: TM-score 0.93, RMSD 2.09 Å
- 2JC6 chain C against the predicted model Q8IU85: TM-score 0.92, RMSD 2.14 Å
Elsewhere
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