UniProt Q8IE47
Transcriptional regulatory protein sir2 homologue (Q8IE47)
Transcriptional regulatory protein sir2 homologue (UniProt Q8IE47), EC 3.5.1.17: 6 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 11 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q8IE47
- Protein
- Transcriptional regulatory protein sir2 homologue
- EC
- 3.5.1.17
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 11 · 7 records with a druggable one
Structures
7 records of Q8IE47 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3JWP | Crystal structure of Plasmodium falciparum SIR2A (PF13_0152) in complex with AMP | x-ray diffraction | A | AMP, ZN | 2 (best 0.77) |
| 3JWP | Crystal structure of plasmodium falciparum SIR2A (PF13_0152) in complex with AMP | x-ray diffraction | A | AMP, ZN | 2 (best 0.77) |
| 3U31 | Plasmodium falciparum Sir2A preferentially hydrolyzes medium and long chain fatty acyl lysine | x-ray diffraction | A | NAD, ZN | 2 (best 0.64) |
| 3U31 | Plasmodium falciparum SIR2A preferentially hydrolyzes medium and long chain fatty acyl lysine | x-ray diffraction | A | NAD, ZN | 2 (best 0.64) |
| 3U3D | Plasmodium falciparum Sir2A preferentially hydrolyzes medium and long chain fatty acyl lysine | x-ray diffraction | A | ZN | 1 (best 0.70) |
| 3U3D | Plasmodium falciparum SIR2A preferentially hydrolyzes medium and long chain fatty acyl lysine | x-ray diffraction | A | ZN | 1 (best 0.70) |
| Q8IE47 | AlphaFold monomer V2.0 prediction for NAD-dependent protein deacylase SIR2A (Q8IE47) | predicted | A | — | 1 (best 0.77) |
Ligands
Experiment against prediction
- 3JWP chain A against the predicted model Q8IE47: TM-score 0.97, RMSD 1.03 Å
- 3JWP chain A against the predicted model Q8IE47: TM-score 0.97, RMSD 1.03 Å
- 3U31 chain A against the predicted model Q8IE47: TM-score 0.97, RMSD 1.24 Å
- 3U31 chain A against the predicted model Q8IE47: TM-score 0.97, RMSD 1.24 Å
- 3U3D chain A against the predicted model Q8IE47: TM-score 0.97, RMSD 1.27 Å
- 3U3D chain A against the predicted model Q8IE47: TM-score 0.97, RMSD 1.27 Å
Elsewhere
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