UniProt Q8IAR7
Tyrosine--tRNA ligase (Q8IAR7)
Tyrosine--tRNA ligase (UniProt Q8IAR7), EC 6.1.1.1: 9 experimental structures on GenesisL1, 6 ligands bound, 18 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q8IAR7
- Protein
- Tyrosine--tRNA ligase
- EC
- 6.1.1.1
- Experimental structures
- 9
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 18 · 4 records with a druggable one
Structures
9 records of Q8IAR7 in the MolNFT archive: 9 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3VGJ | Crystal of Plasmodium falciparum tyrosyl-tRNA synthetase (PfTyrRS)in complex with adenylate analog | x-ray diffraction | A, B | — | — |
| 3VGJ | Crystal of plasmodium falciparum tyrosyl-tRNA synthetase (PFTYRRS)IN complex with adenylate analog | x-ray diffraction | A, B | — | — |
| 7ROR | Plasmodium falciparum tyrosyl-tRNA synthetase in complex with tyrosine-AMP | x-ray diffraction | A, B | 69X, CL, MG | 6 (best 0.78) |
| 7ROR | Plasmodium falciparum tyrosyl-tRNA synthetase in complex with tyrosine-AMP | x-ray diffraction | A, B | 69X, CL, MG | — |
| 7ROS | Plasmodium falciparum tyrosyl-tRNA synthetase in complex with ML901-Tyr | x-ray diffraction | A, B | 66I, MG, CL | 4 (best 0.76) |
| 7ROS | Plasmodium falciparum tyrosyl-tRNA synthetase in complex with ML901- tyr | x-ray diffraction | A, B | 66I, MG, CL | — |
| 7ROT | Plasmodium falciparum tyrosyl-tRNA synthetase, S234C mutant, in complex with ML901-Tyr | x-ray diffraction | A, B | 66I, MG, CL | 4 (best 0.67) |
| 7ROT | Plasmodium falciparum tyrosyl-tRNA synthetase, S234C mutant, in complex with ML901-tyr | x-ray diffraction | A, B | 66I, MG, CL | — |
| 9CLL | Plasmodium falciparum tyrosyl-tRNA synthetase in complex with ML471-Tyr | x-ray diffraction | A, B | A1AZG, CL, NA | 4 (best 0.70) |
Ligands
- CL · Chloride ion · in 7 records
- MG · Magnesium ion · in 6 records
- 66I · {(2R,3S,4R,5R)-5-[4-amino-3-(difluoromethoxy)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxyoxolan-2-yl}methyl [(2S)-2-amino-3-(4-hydroxyphenyl) propanoyl]sulfamate (non-preferred name) · in 4 records
- 69X · 5'-O-[(S)-{[(2S)-2-amino-3-(4-hydroxyphenyl) propanoyl]oxy}(hydroxy)phosphoryl]adenosine · in 2 records
- A1AZG · {(2R,3S,4R,5R)-5-[4-amino-3-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxyoxolan-2-yl}methyl [(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]sulfamate · in 1 record
- NA · Sodium ion · in 1 record
Elsewhere
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