UniProt Q8I4V8
FK506-binding protein (FKBP)-type peptidyl-propyl isomerase (Q8I4V8)
FK506-binding protein (FKBP)-type peptidyl-propyl isomerase (UniProt Q8I4V8), EC 5.2.1.8: 10 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 20 pockets. Binding sites, druggability and experiment…
- UniProt
- Q8I4V8
- Protein
- FK506-binding protein (FKBP)-type peptidyl-propyl isomerase
- EC
- 5.2.1.8
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 20 · 6 records with a druggable one
Structures
11 records of Q8I4V8 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2OFN | Solution structure of FK506-binding domain (FKBD)of FKBP35 from Plasmodium falciparum | solution nmr | A | — | 1 (best 0.64) |
| 2OFN | Solution structure of FK506-binding domain (FKBD)OF FKBP35 from plasmodium falciparum | solution nmr | A | — | 1 (best 0.64) |
| 2VN1 | Crystal structure of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with FK506 | x-ray diffraction | A, B | FK5 | 2 (best 0.75) |
| 2VN1 | Crystal structure of the FK506-binding domain of plasmodium falciparum FKBP35 in complex with FK506 | x-ray diffraction | A, B | FK5 | 2 (best 0.75) |
| 4J4N | Crystal structure of FK506 binding domain of plasmodium falciparum FKBP35 in complex with D44 | x-ray diffraction | A, B, C | D44 | 5 (best 0.78) |
| 4J4N | Crystal structure of FK506 binding domain of plasmodium falciparum FKBP35 in complex with D44 | x-ray diffraction | A, B, C | D44 | 5 (best 0.78) |
| 4QT2 | Crystal Structure of the FK506-Binding Domain of Plasmodium Falciparum FKBP35 in complex with… | x-ray diffraction | A | RAP | 1 (best 0.35) |
| 4QT2 | Crystal structure of the FK506-binding domain of plasmodium falciparum FKBP35 in complex with… | x-ray diffraction | A | RAP | 1 (best 0.35) |
| 4QT3 | Crystal structure resolution of Plasmodium falciparum FK506 binding domain (FKBP35) in complex with… | x-ray diffraction | A | DTV, RAP | 1 (best 0.37) |
| 4QT3 | Crystal structure resolution of plasmodium falciparum FK506 binding domain (FKBP35) in complex with… | x-ray diffraction | A | DTV, RAP | 1 (best 0.37) |
| Q8I4V8 | AlphaFold monomer V2.0 prediction for peptidyl-prolyl cis-trans isomerase FKBP35 (Q8I4V8) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4J4N chain C against the predicted model Q8I4V8: TM-score 0.99, RMSD 0.47 Å
- 4J4N chain C against the predicted model Q8I4V8: TM-score 0.99, RMSD 0.47 Å
- 4J4N chain B against the predicted model Q8I4V8: TM-score 0.98, RMSD 0.59 Å
- 4J4N chain B against the predicted model Q8I4V8: TM-score 0.98, RMSD 0.59 Å
- 2VN1 chain B against the predicted model Q8I4V8: TM-score 0.98, RMSD 0.74 Å
- 2VN1 chain B against the predicted model Q8I4V8: TM-score 0.98, RMSD 0.74 Å
- 4J4N chain A against the predicted model Q8I4V8: TM-score 0.98, RMSD 0.64 Å
- 4J4N chain A against the predicted model Q8I4V8: TM-score 0.98, RMSD 0.64 Å
- 2VN1 chain A against the predicted model Q8I4V8: TM-score 0.98, RMSD 0.67 Å
- 2VN1 chain A against the predicted model Q8I4V8: TM-score 0.98, RMSD 0.67 Å
Elsewhere
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