UniProt Q8HYX6
Peptidyl-prolyl cis-trans isomerase FKBP1B (Q8HYX6)
Peptidyl-prolyl cis-trans isomerase FKBP1B (UniProt Q8HYX6), EC 5.2.1.8: 6 experimental structures and 1 predicted model on GenesisL1, 33 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8HYX6
- Protein
- Peptidyl-prolyl cis-trans isomerase FKBP1B
- EC
- 5.2.1.8
- Experimental structures
- 6
- Predicted models
- 1
- Pockets
- 33 · 6 records with a druggable one
Structures
7 records of Q8HYX6 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8RRT | Structure of rabbit RyR1 reconstituted into lipid liposomes in open state in complex with FKBP and… | electron microscopy | A, D, H, I | — | 7 (best 0.80) |
| 8RRU | Structure of RyR1 reconstituted into lipid liposomes in primed state in complex with FKBP and… | electron microscopy | A, D, H, I | — | 4 (best 0.85) |
| 8RRV | Structure of RyR1 in detergent in close state in complex with FKBP and Nb9657. | electron microscopy | A, D, H, I | — | 6 (best 0.86) |
| 8RRW | Structure of RyR1 in detergent in open state in complex with FKBP and Nb9657. | electron microscopy | A, D, H, I | — | 7 (best 0.87) |
| 8RRX | Structure of RyR1 reconstituted into lipid nanodisc in primed state in complex with Ca2+, ATP… | electron microscopy | H, L, J, F | — | 4 (best 0.88) |
| 8RS0 | Structure of RyR1 in detergent in primed state in complex with nanobody and FKBP | electron microscopy | A, D, H, I | — | 5 (best 0.86) |
| Q8HYX6 | AlphaFold monomer V2.0 prediction for peptidyl-prolyl cis-trans isomerase FKBP1B (Q8HYX6) | predicted | A | — | — |
Experiment against prediction
- 8RRX chain H against the predicted model Q8HYX6: TM-score 0.97, RMSD 0.71 Å
- 8RRX chain J against the predicted model Q8HYX6: TM-score 0.97, RMSD 0.71 Å
- 8RRX chain F against the predicted model Q8HYX6: TM-score 0.97, RMSD 0.71 Å
- 8RRX chain L against the predicted model Q8HYX6: TM-score 0.97, RMSD 0.71 Å
- 8RS0 chain D against the predicted model Q8HYX6: TM-score 0.97, RMSD 0.74 Å
- 8RS0 chain I against the predicted model Q8HYX6: TM-score 0.97, RMSD 0.74 Å
- 8RS0 chain H against the predicted model Q8HYX6: TM-score 0.96, RMSD 0.74 Å
- 8RS0 chain A against the predicted model Q8HYX6: TM-score 0.96, RMSD 0.75 Å
- 8RRU chain H against the predicted model Q8HYX6: TM-score 0.96, RMSD 0.79 Å
- 8RRU chain I against the predicted model Q8HYX6: TM-score 0.96, RMSD 0.79 Å
Elsewhere
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