UniProt Q8DEM0
4-hydroxy-tetrahydrodipicolinate reductase (Q8DEM0)
4-hydroxy-tetrahydrodipicolinate reductase (UniProt Q8DEM0), EC 1.17.1.8: 8 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 61 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8DEM0
- Protein
- 4-hydroxy-tetrahydrodipicolinate reductase
- EC
- 1.17.1.8
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 61 · 4 records with a druggable one
Structures
9 records of Q8DEM0 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5TEJ | Structure of 4-Hydroxy-tetrahydrodipicolinate Reductase from Vibrio vulnificus with 2,5 Furan… | x-ray diffraction | A, B, C, D | NAD, 7FN, NA | 16 (best 0.86) |
| 5TEJ | Structure of 4-hydroxy-tetrahydrodipicolinate reductase from vibrio vulnificus with 2,5 furan… | x-ray diffraction | A, B, C, D | NAD, 7FN, NA | — |
| 5TEM | Structure of 4-Hydroxy-tetrahydrodipicolinate Reductase from Vibrio vulnificus with 2,6 Pyridine… | x-ray diffraction | C, A | NAD, PDC, SO4 | 5 (best 0.72) |
| 5TEM | Structure of 4-hydroxy-tetrahydrodipicolinate reductase from vibrio vulnificus with 2,6 pyridine… | x-ray diffraction | C, A | NAD, PDC, SO4 | — |
| 5TEN | Structure of 4-Hydroxy-tetrahydrodipicolinate Reductase from Vibrio vulnificus with 2,5 Furan… | x-ray diffraction | A, B, C, D, E, F, G, H | NAD, SO4, 7FN | 20 (best 0.86) |
| 5TEN | Structure of 4-hydroxy-tetrahydrodipicolinate reductase from vibrio vulnificus with 2,5 furan… | x-ray diffraction | A, B, C, D, E, F, G, H | NAD, SO4, 7FN | — |
| 5US6 | Structure of Dihydrodipicolinate Reductase from Vibrio vulnificus Bound to NADH and 2,6 Pyridine… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | NAD, PDC, SO4 | 20 (best 0.86) |
| 5US6 | Structure of dihydrodipicolinate reductase from vibrio vulnificus bound to NADH and 2,6 pyridine… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | NAD, PDC, SO4 | — |
| Q8DEM0 | AlphaFold monomer V2.0 prediction for 4-hydroxy- tetrahydrodipicolinate reductase (Q8DEM0) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5US6 chain H against the predicted model Q8DEM0: TM-score 0.98, RMSD 0.97 Å
- 5US6 chain H against the predicted model Q8DEM0: TM-score 0.98, RMSD 0.97 Å
- 5US6 chain D against the predicted model Q8DEM0: TM-score 0.97, RMSD 1.01 Å
- 5US6 chain D against the predicted model Q8DEM0: TM-score 0.97, RMSD 1.01 Å
- 5TEJ chain A against the predicted model Q8DEM0: TM-score 0.96, RMSD 1.33 Å
- 5TEJ chain A against the predicted model Q8DEM0: TM-score 0.96, RMSD 1.33 Å
- 5TEM chain A against the predicted model Q8DEM0: TM-score 0.95, RMSD 1.43 Å
- 5TEM chain A against the predicted model Q8DEM0: TM-score 0.95, RMSD 1.43 Å
- 5TEM chain C against the predicted model Q8DEM0: TM-score 0.94, RMSD 1.56 Å
- 5TEM chain C against the predicted model Q8DEM0: TM-score 0.94, RMSD 1.56 Å
Elsewhere
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