UniProt Q8CIH5
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Q8CIH5)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (UniProt Q8CIH5): 4 experimental structures and 1 predicted model on GenesisL1, 13 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8CIH5
- Protein
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
- Experimental structures
- 4
- Predicted models
- 1
- Pockets
- 13 · 1 record with a druggable one
Structures
5 records of Q8CIH5 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2DX0 | Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2 | x-ray diffraction | A, B | — | — |
| 2DX0 | Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2 | x-ray diffraction | A, B | — | — |
| 2EQI | Solution structure of the SH3 domain from Phospholipase C, gamma 2 | solution nmr | A | — | — |
| 2EQI | Solution structure of the SH3 domain from phospholipase C, gamma 2 | solution nmr | A | — | — |
| Q8CIH5 | AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase… | predicted | A | — | 13 (best 0.80) |
Experiment against prediction
- 2EQI chain A against the predicted model Q8CIH5: TM-score 0.80, RMSD 2.19 Å
- 2EQI chain A against the predicted model Q8CIH5: TM-score 0.80, RMSD 2.19 Å
- 2DX0 chain B against the predicted model Q8CIH5: TM-score 0.80, RMSD 1.32 Å
- 2DX0 chain B against the predicted model Q8CIH5: TM-score 0.80, RMSD 1.32 Å
- 2DX0 chain A against the predicted model Q8CIH5: TM-score 0.79, RMSD 2.29 Å
- 2DX0 chain A against the predicted model Q8CIH5: TM-score 0.79, RMSD 2.29 Å
Elsewhere
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