UniProt Q8CDG1
Piwi-like protein 2 (Q8CDG1)
Piwi-like protein 2 (UniProt Q8CDG1), EC 3.1.26.-: 9 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 56 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8CDG1
- Protein
- Piwi-like protein 2
- EC
- 3.1.26.-
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 56 · 7 records with a druggable one
Structures
10 records of Q8CDG1 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4B9W | Structure of extended Tudor domain TD3 from mouse TDRD1 in complex with MILI peptide containing… | x-ray diffraction | P, S | — | — |
| 4B9W | Structure of extended tudor domain TD3 from mouse TDRD1 in complex with mili peptide containing… | x-ray diffraction | P, S | — | — |
| 7YFY | Cryo-EM structure of the Mili-piRNA- target ternary complex | electron microscopy | A | MG | 12 (best 0.75) |
| 7YGN | Cryo-EM structure of the Mili in complex with piRNA | electron microscopy | A | MG | — |
| 9IJ0 | Cryo-EM Structure of MILI-piRNA-target (8-nt) | electron microscopy | A | MG | 7 (best 0.79) |
| 9IJ1 | Cryo-EM Structure of MILI-piRNA-target (22-nt, bilobed) | electron microscopy | A | MG | 8 (best 0.87) |
| 9IJ2 | Cryo-EM Structure of MILI-piRNA-target (22-nt, comma) | electron microscopy | A | — | 8 (best 0.78) |
| 9IJ3 | Cryo-EM Structure of MILI-piRNA-target (26-nt) | electron microscopy | A | MN | 7 (best 0.80) |
| 9IJ5 | Cryo-EM Structure of MILI(K853A)-piRNA-target | electron microscopy | A | MG | 5 (best 0.84) |
| Q8CDG1 | AlphaFold monomer V2.0 prediction for piwi-like protein 2 (Q8CDG1) | predicted | A | — | 9 (best 0.86) |
Ligands
Experiment against prediction
- 7YGN chain A against the predicted model Q8CDG1: TM-score 0.98, RMSD 1.64 Å
- 9IJ0 chain A against the predicted model Q8CDG1: TM-score 0.94, RMSD 2.59 Å
- 9IJ2 chain A against the predicted model Q8CDG1: TM-score 0.93, RMSD 2.06 Å
- 9IJ5 chain A against the predicted model Q8CDG1: TM-score 0.89, RMSD 3.83 Å
- 9IJ3 chain A against the predicted model Q8CDG1: TM-score 0.88, RMSD 3.75 Å
- 7YFY chain A against the predicted model Q8CDG1: TM-score 0.88, RMSD 3.80 Å
- 9IJ1 chain A against the predicted model Q8CDG1: TM-score 0.87, RMSD 3.98 Å
- 4B9W chain P against the predicted model Q8CDG1: TM-score 0.53, RMSD 1.42 Å
- 4B9W chain P against the predicted model Q8CDG1: TM-score 0.53, RMSD 1.42 Å
Elsewhere
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