UniProt Q86Y39

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (Q86Y39)

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (UniProt Q86Y39): 6 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 4 pockets. Binding sites, druggability and experiment against…

UniProt: Q86Y39
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
Experimental structures: 6
Predicted models: 1
Ligands: 3
Pockets: 4 · 3 records with a druggable one

Structures

7 records of Q86Y39 in the MolNFT archive: 6 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
5XTC	Cryo-EM structure of human respiratory complex I transmembrane arm	electron microscopy	V	CDL, PEE, PLX	2 (best 0.81)
5XTC	Cryo-EM structure of human respiratory complex I transmembrane arm	electron microscopy	V	CDL, PEE, PLX	—
5XTD	Cryo-EM structure of human respiratory complex I	electron microscopy	V	CDL, PEE, PLX	1 (best 0.83)
5XTD	Cryo-EM structure of human respiratory complex I	electron microscopy	V	CDL, PEE, PLX	—
5XTH	Cryo-EM structure of human respiratory supercomplex I1III2IV1	electron microscopy	V	CDL, PEE, PLX	—
5XTI	Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2	electron microscopy	V, BV	CDL, PEE, PLX	—
Q86Y39	AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11…	predicted	A	—	1 (best 0.52)

Ligands

CDL · Cardiolipin · in 6 records
PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 6 records
PLX · (9R,11S)-9-({[(1S)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol · in 6 records

Experiment against prediction

5XTI chain BV against the predicted model Q86Y39: TM-score 0.97, RMSD 0.77 Å
5XTD chain V against the predicted model Q86Y39: TM-score 0.97, RMSD 0.77 Å
5XTD chain V against the predicted model Q86Y39: TM-score 0.97, RMSD 0.77 Å
5XTC chain V against the predicted model Q86Y39: TM-score 0.97, RMSD 0.77 Å
5XTC chain V against the predicted model Q86Y39: TM-score 0.97, RMSD 0.77 Å
5XTH chain V against the predicted model Q86Y39: TM-score 0.97, RMSD 0.77 Å
5XTI chain V against the predicted model Q86Y39: TM-score 0.97, RMSD 0.77 Å

Elsewhere

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