UniProt Q86WX3
Active regulator of SIRT1 (Q86WX3)
Active regulator of SIRT1 (UniProt Q86WX3): 2 experimental structures and 1 predicted model on GenesisL1, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q86WX3
- Protein
- Active regulator of SIRT1
- Experimental structures
- 2
- Predicted models
- 1
- Pockets
- 13 · 1 record with a druggable one
Structures
3 records of Q86WX3 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7MQA | Cryo-EM structure of the human SSU processome, state post-A1 | electron microscopy | LY | — | — |
| 8BBK | Crystal structure of human Sirt3 in complex with a fragment of the human AROS protein | x-ray diffraction | G, H, I, J, K, L | — | 13 (best 0.72) |
| Q86WX3 | AlphaFold monomer V2.0 prediction for active regulator of SIRT1 (Q86WX3) | predicted | A | — | — |
Experiment against prediction
- 8BBK chain K against the predicted model Q86WX3: TM-score 1.00, RMSD 0.01 Å
- 8BBK chain H against the predicted model Q86WX3: TM-score 1.00, RMSD 0.03 Å
- 8BBK chain L against the predicted model Q86WX3: TM-score 1.00, RMSD 0.03 Å
- 8BBK chain G against the predicted model Q86WX3: TM-score 0.99, RMSD 0.04 Å
- 8BBK chain I against the predicted model Q86WX3: TM-score 0.98, RMSD 0.06 Å
- 8BBK chain J against the predicted model Q86WX3: TM-score 0.96, RMSD 0.10 Å
- 7MQA chain LY against the predicted model Q86WX3: TM-score 0.26, RMSD 3.22 Å
Elsewhere
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