UniProt Q86UW9
Probable E3 ubiquitin-protein ligase DTX2 (Q86UW9)
Probable E3 ubiquitin-protein ligase DTX2 (UniProt Q86UW9), EC 2.3.2.27: 8 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q86UW9
- Protein
- Probable E3 ubiquitin-protein ligase DTX2
- EC
- 2.3.2.27
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 7 · 1 record with a druggable one
Structures
9 records of Q86UW9 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6IR0 | Zinc finger domain of the human DTX protein | solution nmr | A | ZN | — |
| 6IR0 | Zinc finger domain of the human dtx protein | solution nmr | A | ZN | — |
| 6Y22 | RING-DTC domains of Deltex 2, Form 1 | x-ray diffraction | A | ZN | 1 (best 0.46) |
| 6Y22 | Ring-dtc domains of deltex 2, form 1 | x-ray diffraction | A | ZN | — |
| 6Y2X | RING-DTC domains of Deltex 2, Form 2 | x-ray diffraction | A, B | ZN | 4 (best 0.51) |
| 6Y2X | Ring-dtc domains of deltex 2, form 2 | x-ray diffraction | A, B | ZN | — |
| 6Y3J | RING-DTC domains of Deltex 2, bound to ADP-ribose | x-ray diffraction | A | APR, ZN | 2 (best 0.47) |
| 6Y3J | Ring-dtc domains of deltex 2, bound to ADP-ribose | x-ray diffraction | A | APR, ZN | — |
| Q86UW9 | AlphaFold monomer V2.0 prediction for probable E3 ubiquitin-protein ligase DTX2 (Q86UW9) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6Y22 chain A against the predicted model Q86UW9: TM-score 0.98, RMSD 0.95 Å
- 6Y22 chain A against the predicted model Q86UW9: TM-score 0.98, RMSD 0.95 Å
- 6Y3J chain A against the predicted model Q86UW9: TM-score 0.97, RMSD 0.96 Å
- 6Y3J chain A against the predicted model Q86UW9: TM-score 0.97, RMSD 0.96 Å
- 6Y2X chain B against the predicted model Q86UW9: TM-score 0.97, RMSD 0.82 Å
- 6Y2X chain B against the predicted model Q86UW9: TM-score 0.97, RMSD 0.82 Å
- 6Y2X chain A against the predicted model Q86UW9: TM-score 0.84, RMSD 2.75 Å
- 6Y2X chain A against the predicted model Q86UW9: TM-score 0.84, RMSD 2.75 Å
- 6IR0 chain A against the predicted model Q86UW9: TM-score 0.77, RMSD 2.31 Å
- 6IR0 chain A against the predicted model Q86UW9: TM-score 0.77, RMSD 2.31 Å
Elsewhere
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