UniProt Q86UE8
Serine/threonine-protein kinase tousled-like 2 (Q86UE8)
Serine/threonine-protein kinase tousled-like 2 (UniProt Q86UE8), EC 2.7.11.1: 3 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 6 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q86UE8
- Protein
- Serine/threonine-protein kinase tousled-like 2
- EC
- 2.7.11.1
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 6 · 2 records with a druggable one
Structures
4 records of Q86UE8 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5O0Y | TLK2 kinase domain from human | x-ray diffraction | A | AGS | 1 (best 0.65) |
| 5O0Y | TLK2 kinase domain from human | x-ray diffraction | A | AGS | — |
| 7LO0 | Structure of human ASF1A in complex with a TLK2 peptide | x-ray diffraction | I, J, K, L, M, N, O, P, Q, R, T, U, V, W, X, Y | — | — |
| Q86UE8 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase tousled-like 2 (Q86UE8) | predicted | A | — | 5 (best 0.81) |
Ligands
- AGS · Phosphothiophosphoric acid-adenylate ester · in 2 records
Experiment against prediction
- 5O0Y chain A against the predicted model Q86UE8: TM-score 0.96, RMSD 1.25 Å
- 5O0Y chain A against the predicted model Q86UE8: TM-score 0.96, RMSD 1.25 Å
- 7LO0 chain I against the predicted model Q86UE8: TM-score 0.73, RMSD 0.54 Å
- 7LO0 chain L against the predicted model Q86UE8: TM-score 0.71, RMSD 0.28 Å
- 7LO0 chain O against the predicted model Q86UE8: TM-score 0.69, RMSD 0.44 Å
- 7LO0 chain Q against the predicted model Q86UE8: TM-score 0.63, RMSD 0.49 Å
- 7LO0 chain N against the predicted model Q86UE8: TM-score 0.57, RMSD 1.64 Å
- 7LO0 chain R against the predicted model Q86UE8: TM-score 0.54, RMSD 0.79 Å
Elsewhere
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