UniProt Q837V6
DNA ligase, NAD-dependent (Q837V6)
DNA ligase, NAD-dependent (UniProt Q837V6), EC 6.5.1.2: 23 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q837V6
- Protein
- DNA ligase, NAD-dependent
- EC
- 6.5.1.2
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 14 · 3 records with a druggable one
Structures
24 records of Q837V6 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1TA8 | Structural rearrangement accompanying NAD+ synthesis within a bacterial DNA ligase crystal | x-ray diffraction | A | SO4, NMN | 3 (best 0.71) |
| 1TA8 | Structural rearrangement accompanying NAD+ synthesis within a bacterial DNA ligase crystal | x-ray diffraction | A | — | — |
| 1TAE | Structural rearrangement accompanying NAD+ synthesis within a bacterial DNA ligase crystal | x-ray diffraction | A | SO4, NAD | 8 (best 0.85) |
| 1TAE | Structural rearrangement accompanying NAD+ synthesis within a bacterial DNA ligase crystal | x-ray diffraction | A | — | — |
| 3BA8 | Structural Basis for the Inhibition of Bacterial NAD+ Dependent DNA Ligase | x-ray diffraction | A | — | — |
| 3BA8 | Structural basis for the inhibition of bacterial NAD+ dependent DNA ligase | x-ray diffraction | A | — | — |
| 3BA9 | Structural Basis for Inhbition of NAD-Dependent Ligase | x-ray diffraction | A | — | — |
| 3BA9 | Structural basis for inhbition of NAD-dependent ligase | x-ray diffraction | A | — | — |
| 3BAA | Structural Basis for the Inhibition of Bacterial NAD+ Dependent DNA Ligase | x-ray diffraction | A | — | — |
| 3BAA | Structural basis for the inhibition of bacterial NAD+ dependent DNA ligase | x-ray diffraction | A | — | — |
| 3BAB | Structural Basis for the Inhibition of Bacterial NAD+ Dependent DNA Ligase | x-ray diffraction | A | — | — |
| 3BAB | Structural basis for the inhibition of bacterial NAD+ dependent DNA ligase | x-ray diffraction | A | — | — |
| 4EEQ | Crystal structure of E. faecalis DNA ligase with inhibitor | x-ray diffraction | A | — | — |
| 4EEQ | Crystal structure of E. faecalis DNA ligase with inhibitor | x-ray diffraction | A | — | — |
| 4EFB | Crystal structure of DNA ligase | x-ray diffraction | A | — | — |
| 4EFB | Crystal structure of DNA ligase | x-ray diffraction | A | — | — |
| 4EFE | crystal structure of DNA ligase | x-ray diffraction | A | — | — |
| 4EFE | Crystal structure of DNA ligase | x-ray diffraction | A | — | — |
| 4LH6 | Crystal structure of a LigA inhibitor | x-ray diffraction | A | — | — |
| 4LH6 | Crystal structure of a liga inhibitor | x-ray diffraction | A | — | — |
| 4LH7 | Crystal structure of a LigA inhibitor | x-ray diffraction | A | — | — |
| 4LH7 | Crystal structure of a liga inhibitor | x-ray diffraction | A | — | — |
| 8JYD | A genetically encoded sensor based on a bacterial DNA ligase | x-ray diffraction | A | NMN | 3 (best 0.84) |
| Q837V6 | AlphaFold monomer V2.0 prediction for DNA ligase (Q837V6) | predicted | A | — | — |
Ligands
Experiment against prediction
- 3BA9 chain A against the predicted model Q837V6: TM-score 0.99, RMSD 0.79 Å
- 3BA9 chain A against the predicted model Q837V6: TM-score 0.99, RMSD 0.79 Å
- 3BAB chain A against the predicted model Q837V6: TM-score 0.99, RMSD 0.79 Å
- 3BAB chain A against the predicted model Q837V6: TM-score 0.99, RMSD 0.79 Å
- 3BA8 chain A against the predicted model Q837V6: TM-score 0.99, RMSD 0.79 Å
- 3BA8 chain A against the predicted model Q837V6: TM-score 0.99, RMSD 0.79 Å
- 4EEQ chain A against the predicted model Q837V6: TM-score 0.99, RMSD 0.80 Å
- 4EEQ chain A against the predicted model Q837V6: TM-score 0.99, RMSD 0.80 Å
- 4EFB chain A against the predicted model Q837V6: TM-score 0.99, RMSD 0.81 Å
- 4EFB chain A against the predicted model Q837V6: TM-score 0.99, RMSD 0.81 Å
Elsewhere
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