UniProt Q7Z7L1
Schlafen family member 11 (Q7Z7L1)
Schlafen family member 11 (UniProt Q7Z7L1), EC 3.6.-.-: 8 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 155 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q7Z7L1
- Protein
- Schlafen family member 11
- EC
- 3.6.-.-
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 155 · 9 records with a druggable one
Structures
9 records of Q7Z7L1 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7ZEL | Human SLFN11 dimer apoenzyme | electron microscopy | A, B | ZN, MG | 18 (best 0.78) |
| 7ZEP | Human SLFN11 E209A dimer | electron microscopy | A, B | ZN | 20 (best 0.77) |
| 7ZES | Human SLFN11 dimer bound to ssDNA | electron microscopy | A, B | ZN, MG | 20 (best 0.77) |
| 9ERD | Human SLFN11 S753D monomer | electron microscopy | A | MG, ATP, ZN | 9 (best 0.82) |
| 9ERE | SLFN11 dimer bound to tRNA-Leu-TAA | electron microscopy | A, B | ZN, MN | 19 (best 0.77) |
| 9ERF | SLFN11 dimer bound to tRNA-Met-CAT | electron microscopy | A, B | ZN, MN, MG | 20 (best 0.82) |
| 9GMW | SLFN11 WT dimer bound to tRNA-Leu-TAA (pre-cleavage state) | electron microscopy | A, B | ZN, MN | 20 (best 0.74) |
| 9GMX | SLFN11 WT dimer bound to tRNA-Leu-TAA (post-cleavage state) | electron microscopy | A, B | ZN, MN | 19 (best 0.74) |
| Q7Z7L1 | AlphaFold monomer V2.0 prediction for schlafen family member 11 (Q7Z7L1) | predicted | A | — | 10 (best 0.82) |
Ligands
Experiment against prediction
- 9ERD chain A against the predicted model Q7Z7L1: TM-score 0.97, RMSD 1.81 Å
- 7ZEL chain A against the predicted model Q7Z7L1: TM-score 0.65, RMSD 4.39 Å
- 9ERE chain A against the predicted model Q7Z7L1: TM-score 0.65, RMSD 4.19 Å
- 9ERF chain A against the predicted model Q7Z7L1: TM-score 0.65, RMSD 4.15 Å
- 7ZEP chain A against the predicted model Q7Z7L1: TM-score 0.65, RMSD 4.33 Å
- 9GMX chain A against the predicted model Q7Z7L1: TM-score 0.65, RMSD 4.17 Å
- 9GMW chain A against the predicted model Q7Z7L1: TM-score 0.65, RMSD 4.16 Å
- 7ZES chain A against the predicted model Q7Z7L1: TM-score 0.65, RMSD 4.17 Å
Elsewhere
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