UniProt Q7Z6J9
tRNA-splicing endonuclease subunit Sen54 (Q7Z6J9)
tRNA-splicing endonuclease subunit Sen54 (UniProt Q7Z6J9): 5 experimental structures and 1 predicted model on GenesisL1, 61 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q7Z6J9
- Protein
- tRNA-splicing endonuclease subunit Sen54
- Experimental structures
- 5
- Predicted models
- 1
- Pockets
- 61 · 6 records with a druggable one
Structures
6 records of Q7Z6J9 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7UXA | Human tRNA Splicing Endonuclease Complex bound to pre-tRNA-ARG | electron microscopy | D | — | 11 (best 0.81) |
| 7ZRZ | Structure of the human tRNA splicing endonuclease defines substrate recognition | electron microscopy | CP1 | — | 11 (best 0.86) |
| 8HMY | Cryo-EM structure of the human pre-catalytic TSEN/pre-tRNA complex | electron microscopy | C | — | 9 (best 0.82) |
| 8HMZ | Cryo-EM structure of the human post-catalytic TSEN/pre-tRNA complex | electron microscopy | C | — | 10 (best 0.83) |
| 8ISS | Cryo-EM structure of wild-type human tRNA Splicing Endonuclease Complex bound to pre-tRNA-ARG at… | electron microscopy | D | — | 12 (best 0.81) |
| Q7Z6J9 | AlphaFold monomer V2.0 prediction for tRNA-splicing endonuclease subunit SEN54 (Q7Z6J9) | predicted | A | — | 8 (best 0.51) |
Experiment against prediction
- 7ZRZ chain CP1 against the predicted model Q7Z6J9: TM-score 0.87, RMSD 2.65 Å
- 7UXA chain D against the predicted model Q7Z6J9: TM-score 0.85, RMSD 2.77 Å
- 8HMZ chain C against the predicted model Q7Z6J9: TM-score 0.82, RMSD 3.16 Å
- 8HMY chain C against the predicted model Q7Z6J9: TM-score 0.82, RMSD 3.16 Å
- 8ISS chain D against the predicted model Q7Z6J9: TM-score 0.80, RMSD 3.20 Å
Elsewhere
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