UniProt Q7Z2E3
Aprataxin (Q7Z2E3)
Aprataxin (UniProt Q7Z2E3), EC 3.1.11.7, 3.1.12.2: 18 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 26 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q7Z2E3
- Protein
- Aprataxin
- EC
- 3.1.11.7, 3.1.12.2
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 26 · 4 records with a druggable one
Structures
19 records of Q7Z2E3 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4NDF | Human Aprataxin (Aptx) bound to RNA-DNA, AMP, and Zn - product complex | x-ray diffraction | A, B | — | — |
| 4NDF | Human aprataxin (aptx) bound to RNA-DNA, AMP, and zn - product complex | x-ray diffraction | A, B | — | — |
| 4NDG | Human Aprataxin (Aptx) bound to RNA-DNA and Zn - adenosine vanadate transition state mimic complex | x-ray diffraction | A, B | — | — |
| 4NDG | Human aprataxin (aptx) bound to RNA-DNA and zn - adenosine vanadate transition state mimic complex | x-ray diffraction | A, B | — | — |
| 4NDH | Human Aprataxin (Aptx) bound to DNA, AMP, and Zn - product complex | x-ray diffraction | A, B | — | — |
| 4NDH | Human aprataxin (aptx) bound to DNA, AMP, and zn - product complex | x-ray diffraction | A, B | — | — |
| 4NDI | Human Aprataxin (Aptx) AOA1 variant K197Q bound to RNA-DNA, AMP, and Zn - product complex | x-ray diffraction | A, B | — | — |
| 4NDI | Human aprataxin (aptx) AOA1 variant K197Q bound to RNA-DNA, AMP, and zn - product complex | x-ray diffraction | A, B | — | — |
| 6CVO | Human Aprataxin (Aptx) bound to nicked RNA-DNA, AMP and Zn product complex | x-ray diffraction | A, B | AMP, ZN | 6 (best 0.72) |
| 6CVO | Human aprataxin (aptx) bound to nicked RNA-DNA, AMP and zn product complex | x-ray diffraction | A, B | AMP, ZN | — |
| 6CVP | Human Aprataxin (Aptx) R199H bound to RNA-DNA, AMP and Zn product complex | x-ray diffraction | A, B | AMP, ZN, NA | 6 (best 0.66) |
| 6CVP | Human aprataxin (aptx) R199H bound to RNA-DNA, AMP and zn product complex | x-ray diffraction | A, B | AMP, ZN, NA | — |
| 6CVQ | Human Aprataxin (Aptx) H201Q bound to RNA-DNA, AMP and Zn product complex | x-ray diffraction | A, B | AMP, ZN, NA | 7 (best 0.75) |
| 6CVQ | Human aprataxin (aptx) H201Q bound to RNA-DNA, AMP and zn product complex | x-ray diffraction | A, B | AMP, ZN, NA | — |
| 6CVR | Human Aprataxin (Aptx) S242N bound to RNA-DNA, AMP and Zn product complex | x-ray diffraction | A, B | AMP, ZN | 7 (best 0.77) |
| 6CVR | Human aprataxin (aptx) S242N bound to RNA-DNA, AMP and zn product complex | x-ray diffraction | A, B | AMP, ZN | — |
| 6CVS | Human aprataxin (aptx) L248M bound to DNA, AMP and zn product | x-ray diffraction | A, B | AMP, ZN | — |
| 6CVT | Human aprataxin (aptx) V263G bound to RNA-DNA, AMP and zn product complex | x-ray diffraction | A, B | ZN, AMP | — |
| Q7Z2E3 | AlphaFold monomer V2.0 prediction for aprataxin (Q7Z2E3) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6CVO chain A against the predicted model Q7Z2E3: TM-score 0.98, RMSD 0.65 Å
- 6CVO chain A against the predicted model Q7Z2E3: TM-score 0.98, RMSD 0.65 Å
- 6CVT chain A against the predicted model Q7Z2E3: TM-score 0.98, RMSD 0.70 Å
- 6CVS chain B against the predicted model Q7Z2E3: TM-score 0.98, RMSD 0.80 Å
- 4NDH chain B against the predicted model Q7Z2E3: TM-score 0.98, RMSD 0.81 Å
- 4NDH chain B against the predicted model Q7Z2E3: TM-score 0.98, RMSD 0.81 Å
- 6CVP chain A against the predicted model Q7Z2E3: TM-score 0.98, RMSD 0.67 Å
- 6CVP chain A against the predicted model Q7Z2E3: TM-score 0.98, RMSD 0.67 Å
- 6CVR chain B against the predicted model Q7Z2E3: TM-score 0.98, RMSD 0.81 Å
- 6CVR chain B against the predicted model Q7Z2E3: TM-score 0.98, RMSD 0.81 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.