UniProt Q7L2H7
Eukaryotic translation initiation factor 3 subunit M (Q7L2H7)
Eukaryotic translation initiation factor 3 subunit M (UniProt Q7L2H7): 21 experimental structures and 1 predicted model on GenesisL1, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q7L2H7
- Protein
- Eukaryotic translation initiation factor 3 subunit M
- Experimental structures
- 21
- Predicted models
- 1
- Pockets
- 15 · 9 records with a druggable one
Structures
22 records of Q7L2H7 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6FEC | Human cap-dependent 48S pre-initiation complex | electron microscopy | 8 | — | — |
| 6YBD | Structure of a human 48S translational initiation complex - eIF3 | electron microscopy | 6 | — | 4 (best 0.83) |
| 6YBD | Structure of a human 48S translational initiation complex - EIF3 | electron microscopy | 6 | — | — |
| 6ZMW | Structure of a human 48S translational initiation complex | electron microscopy | 6 | — | — |
| 6ZON | SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 1 | electron microscopy | M | — | — |
| 6ZP4 | SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 2 | electron microscopy | M | — | — |
| 6ZVJ | Structure of a human ABCE1-bound 43S pre-initiation complex - State II | electron microscopy | M | — | — |
| 7A09 | Structure of a human ABCE1-bound 43S pre-initiation complex - State III | electron microscopy | M | — | — |
| 7QP6 | Structure of the human 48S initiation complex in open state (h48S AUG open) | electron microscopy | 6 | — | 1 (best 0.86) |
| 7QP7 | Structure of the human 48S initiation complex in closed state (h48S AUG closed) | electron microscopy | 6 | — | 1 (best 0.84) |
| 8OZ0 | Structure of a human 48S translation initiation complex with eIF4F and eIF4A | electron microscopy | C | — | — |
| 8PJ1 | Structure of human 48S translation initiation complex in open codon scanning state (48S-1) | electron microscopy | 6 | — | — |
| 8PJ2 | Structure of human 48S translation initiation complex in AUG recognition state after eIF5-induced… | electron microscopy | 6 | — | 1 (best 0.84) |
| 8PJ3 | Structure of human 48S translation initiation complex upon transfer of initiator tRNA to eIF5B… | electron microscopy | 6 | — | 1 (best 0.85) |
| 8PJ4 | Structure of human 48S translation initiation complex after eIF5 release (48S-4) | electron microscopy | 6 | — | 1 (best 0.85) |
| 8PJ5 | Structure of human 48S translation initiation complex after eIF2 release prior 60S subunit joining… | electron microscopy | 6 | — | — |
| 8PJ6 | Structure of human 48S translation initiation complex with initiator tRNA, eIF1A and eIF3… | electron microscopy | 6 | — | 1 (best 0.85) |
| 8PPL | MERS-CoV Nsp1 bound to the human 43S pre-initiation complex | electron microscopy | I6 | — | — |
| 8RG0 | Structure of human eIF3 core from closed 48S translation initiation complex | electron microscopy | 6 | — | 4 (best 0.87) |
| 8XXN | Cryo-EM structure of the human 43S ribosome with PDCD4 | electron microscopy | 3M | — | 1 (best 0.84) |
| 9BLN | The structure of human Pdcd4 bound to the 40S-eIF4A-eIF3-eIF1 complex | electron microscopy | 6 | — | — |
| Q7L2H7 | AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit M (Q7L2H7) | predicted | A | — | — |
Experiment against prediction
- 8OZ0 chain C against the predicted model Q7L2H7: TM-score 0.83, RMSD 3.40 Å
- 6ZON chain M against the predicted model Q7L2H7: TM-score 0.82, RMSD 3.36 Å
- 6ZP4 chain M against the predicted model Q7L2H7: TM-score 0.82, RMSD 3.27 Å
- 8XXN chain 3M against the predicted model Q7L2H7: TM-score 0.81, RMSD 3.42 Å
- 6ZVJ chain M against the predicted model Q7L2H7: TM-score 0.81, RMSD 3.38 Å
- 8RG0 chain 6 against the predicted model Q7L2H7: TM-score 0.81, RMSD 3.25 Å
- 8PJ2 chain 6 against the predicted model Q7L2H7: TM-score 0.81, RMSD 3.20 Å
- 8PJ4 chain 6 against the predicted model Q7L2H7: TM-score 0.81, RMSD 3.31 Å
- 8PJ3 chain 6 against the predicted model Q7L2H7: TM-score 0.81, RMSD 3.22 Å
- 7A09 chain M against the predicted model Q7L2H7: TM-score 0.81, RMSD 3.46 Å
Elsewhere
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