UniProt Q74H36
CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion (Q74H36)
CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion (UniProt Q74H36), EC 3.1.-.-, 3.1.12.1: 10 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 92 pockets. Binding sites, druggability and…
- UniProt
- Q74H36
- Protein
- CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion
- EC
- 3.1.-.-, 3.1.12.1
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 92 · 5 records with a druggable one
Structures
11 records of Q74H36 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7MI4 | Symmetrical PAM-PAM prespacer bound Cas4/Cas1/Cas2 complex | electron microscopy | A, B, C, D | SF4, MN | 20 (best 0.83) |
| 7MI4 | Symmetrical pam-pam prespacer bound CAS4/CAS1/CAS2 complex | electron microscopy | A, B, C, D | SF4, MN | — |
| 7MI5 | Asymmetrical PAM-Non PAM prespacer bound Cas4/Cas1/Cas2 complex | electron microscopy | A, B, C, D | SF4, MN | 19 (best 0.83) |
| 7MI5 | Asymmetrical pam-non pam prespacer bound CAS4/CAS1/CAS2 complex | electron microscopy | A, B, C, D | SF4, MN | — |
| 7MI9 | Full integration complex of Cas1/Cas2 from Cas4-containing system | electron microscopy | A, B, C, D | — | 18 (best 0.85) |
| 7MI9 | Full integration complex of CAS1/CAS2 from CAS4-containing system | electron microscopy | A, B, C, D | — | — |
| 7MIB | Half integration complex of Cas4/Cas1/Cas2 with Cas4 still on the Non-PAM side | electron microscopy | A, B, C, D | — | 19 (best 0.88) |
| 7MIB | Half integration complex of CAS4/CAS1/CAS2 with CAS4 still on the non- pam side | electron microscopy | A, B, C, D | — | — |
| 7MID | Sub-complex of Cas4-Cas1-Cas2 bound PAM containing DNA | electron microscopy | A, B | SF4, MN | 16 (best 0.82) |
| 7MID | Sub-complex of CAS4-CAS1-CAS2 bound pam containing DNA | electron microscopy | A, B | SF4, MN | — |
| Q74H36 | AlphaFold monomer V2.0 prediction for CRISPR-associated exonuclease CAS4/ENDONUCLEASE CAS1 fusion… | predicted | A | — | — |
Ligands
Experiment against prediction
- 7MI4 chain A against the predicted model Q74H36: TM-score 0.97, RMSD 1.56 Å
- 7MI4 chain A against the predicted model Q74H36: TM-score 0.97, RMSD 1.56 Å
- 7MID chain A against the predicted model Q74H36: TM-score 0.97, RMSD 1.56 Å
- 7MID chain A against the predicted model Q74H36: TM-score 0.97, RMSD 1.56 Å
- 7MI4 chain C against the predicted model Q74H36: TM-score 0.97, RMSD 1.56 Å
- 7MI4 chain C against the predicted model Q74H36: TM-score 0.97, RMSD 1.56 Å
- 7MI5 chain A against the predicted model Q74H36: TM-score 0.96, RMSD 1.69 Å
- 7MI5 chain A against the predicted model Q74H36: TM-score 0.96, RMSD 1.69 Å
- 7MIB chain C against the predicted model Q74H36: TM-score 0.96, RMSD 1.69 Å
- 7MIB chain C against the predicted model Q74H36: TM-score 0.96, RMSD 1.69 Å
Elsewhere
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