UniProt Q74H35
CRISPR-associated endoribonuclease Cas2 (Q74H35)
CRISPR-associated endoribonuclease Cas2 (UniProt Q74H35), EC 3.1.-.-: 8 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 18 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q74H35
- Protein
- CRISPR-associated endoribonuclease Cas2
- EC
- 3.1.-.-
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 18 · 3 records with a druggable one
Structures
9 records of Q74H35 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7MI4 | Symmetrical pam-pam prespacer bound CAS4/CAS1/CAS2 complex | electron microscopy | E, F | MN | — |
| 7MI5 | Asymmetrical PAM-Non PAM prespacer bound Cas4/Cas1/Cas2 complex | electron microscopy | E, F | MN | 5 (best 0.83) |
| 7MI5 | Asymmetrical pam-non pam prespacer bound CAS4/CAS1/CAS2 complex | electron microscopy | E, F | MN | — |
| 7MI9 | Full integration complex of Cas1/Cas2 from Cas4-containing system | electron microscopy | E, F | — | 9 (best 0.75) |
| 7MI9 | Full integration complex of CAS1/CAS2 from CAS4-containing system | electron microscopy | E, F | — | — |
| 7MIB | Half integration complex of Cas4/Cas1/Cas2 with Cas4 still on the Non-PAM side | electron microscopy | E, F | — | 4 (best 0.88) |
| 7MIB | Half integration complex of CAS4/CAS1/CAS2 with CAS4 still on the non- pam side | electron microscopy | E, F | — | — |
| 7MID | Sub-complex of CAS4-CAS1-CAS2 bound pam containing DNA | electron microscopy | C, D | MN | — |
| Q74H35 | AlphaFold monomer V2.0 prediction for CRISPR-associated endoribonuclease CAS2 (Q74H35) | predicted | A | — | — |
Ligands
- MN · Manganese (II) ion · in 4 records
Experiment against prediction
- 7MID chain D against the predicted model Q74H35: TM-score 0.88, RMSD 1.56 Å
- 7MI4 chain E against the predicted model Q74H35: TM-score 0.86, RMSD 1.71 Å
- 7MI4 chain F against the predicted model Q74H35: TM-score 0.86, RMSD 1.71 Å
- 7MID chain C against the predicted model Q74H35: TM-score 0.86, RMSD 1.71 Å
- 7MI5 chain F against the predicted model Q74H35: TM-score 0.85, RMSD 1.77 Å
- 7MI5 chain F against the predicted model Q74H35: TM-score 0.85, RMSD 1.77 Å
- 7MI5 chain E against the predicted model Q74H35: TM-score 0.85, RMSD 1.77 Å
- 7MI5 chain E against the predicted model Q74H35: TM-score 0.85, RMSD 1.77 Å
- 7MI9 chain E against the predicted model Q74H35: TM-score 0.85, RMSD 1.82 Å
- 7MI9 chain E against the predicted model Q74H35: TM-score 0.85, RMSD 1.82 Å
Elsewhere
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