UniProt Q72IW9
Homoisocitrate dehydrogenase (Q72IW9)
Homoisocitrate dehydrogenase (UniProt Q72IW9), EC 1.1.1.87: 4 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 64 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q72IW9
- Protein
- Homoisocitrate dehydrogenase
- EC
- 1.1.1.87
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 64 · 4 records with a druggable one
Structures
5 records of Q72IW9 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3AH3 | Crystal structure of LR5-1, 3-isopropylmalate dehydrogenase created by directed evolution | x-ray diffraction | A, B, C, D | SO4 | 12 (best 0.86) |
| 3AH3 | Crystal structure of LR5-1, 3-isopropylmalate dehydrogenase created by directed evolution | x-ray diffraction | A, B, C, D | SO4 | 12 (best 0.86) |
| 4YB4 | Crystal structure of homoisocitrate dehydrogenase from Thermus thermophilus in complex with… | x-ray diffraction | A, B, C, D | MG, 48Y, NAI, SO4 | 20 (best 0.75) |
| 4YB4 | Crystal structure of homoisocitrate dehydrogenase from thermus thermophilus in complex with… | x-ray diffraction | A, B, C, D | MG, 48Y, NAI, SO4 | 20 (best 0.75) |
| Q72IW9 | AlphaFold monomer V2.0 prediction for homoisocitrate dehydrogenase (Q72IW9) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4YB4 chain A against the predicted model Q72IW9: TM-score 0.99, RMSD 0.53 Å
- 4YB4 chain A against the predicted model Q72IW9: TM-score 0.99, RMSD 0.53 Å
- 3AH3 chain A against the predicted model Q72IW9: TM-score 0.91, RMSD 2.30 Å
- 3AH3 chain A against the predicted model Q72IW9: TM-score 0.91, RMSD 2.30 Å
Elsewhere
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