UniProt Q72HR2
50S ribosomal protein L21 (Q72HR2)
50S ribosomal protein L21 (UniProt Q72HR2): 27 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 33 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q72HR2
- Protein
- 50S ribosomal protein L21
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 33 · 12 records with a druggable one
Structures
28 records of Q72HR2 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4V4I | Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements. | x-ray diffraction | P | — | — |
| 4V4J | Interactions and Dynamics of the Shine-Dalgarno Helix in the 70S Ribosome. | x-ray diffraction | P | — | — |
| 4V63 | Structural basis for translation termination on the 70S ribosome. | x-ray diffraction | BV, DV | — | — |
| 4V67 | Crystal structure of a translation termination complex formed with release factor RF2. | x-ray diffraction | BV, DV | — | — |
| 4V7P | Recognition of the amber stop codon by release factor RF1. | x-ray diffraction | BR, CR | — | — |
| 4V83 | Crystal structure of a complex containing domain 3 from the PSIV IGR IRES RNA bound to the 70S… | x-ray diffraction | BR, DR | — | — |
| 4V84 | Crystal structure of a complex containing domain 3 of CrPV IGR IRES RNA bound to the 70S ribosome. | x-ray diffraction | BR, DR | — | — |
| 4V9J | 70S ribosome translocation intermediate GDPNP-II containing elongation factor EFG/GDPNP, mRNA, and… | x-ray diffraction | BV, DV | — | — |
| 4V9K | 70S ribosome translocation intermediate GDPNP-I containing elongation factor EFG/GDPNP, mRNA, and… | x-ray diffraction | BV, DV | — | — |
| 4V9L | 70S Ribosome translocation intermediate FA-3.6A containing elongation factor EFG/FUSIDIC ACID/GDP… | x-ray diffraction | BV, DV | — | — |
| 4V9M | 70S Ribosome translocation intermediate FA-4.2A containing elongation factor EFG/FUSIDIC ACID/GDP… | x-ray diffraction | BV, DV | — | — |
| 4V9N | Crystal structure of the 70S ribosome bound with the Q253P mutant of release factor RF2. | x-ray diffraction | BV, DV | — | — |
| 4V9Q | Crystal Structure of Blasticidin S Bound to Thermus Thermophilus 70S Ribosome. | x-ray diffraction | AR, CR | — | — |
| 4W29 | 70S ribosome translocation intermediate containing elongation factor EFG/GDP/fusidic acid, mRNA… | x-ray diffraction | BV, DV | — | — |
| 4XEJ | IRES bound to bacterial Ribosome | x-ray diffraction | AL21, BL21 | — | 2 (best 0.89) |
| 4ZER | Crystal structure of the Onc112 antimicrobial peptide bound to the Thermus thermophilus 70S ribosome | x-ray diffraction | 1V, 2V | MG | 3 (best 0.90) |
| 5E81 | Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with wobble… | x-ray diffraction | D8, 95 | MG | 3 (best 0.90) |
| 5J4D | E. coli release factor 1 bound to the 70S ribosome in response to a pseudouridylated stop codon | x-ray diffraction | S, XB | MG | 3 (best 0.90) |
| 5V8I | Thermus thermophilus 70S ribosome lacking ribosomal protein uS17 | x-ray diffraction | 1V, 2V | MG | 4 (best 0.90) |
| 6B4V | Antibiotic blasticidin S and E. coli release factor 1 bound to the 70S ribosome | x-ray diffraction | S, WB | MG | 3 (best 0.89) |
| 6BOH | Antibiotic blasticidin S and E. coli release factor 1 (containing deletion 302-304) bound to the… | x-ray diffraction | S, XB | MG | 3 (best 0.89) |
| 6BOK | E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome | x-ray diffraction | S, VB | MG | — |
| 6C5L | Conformation of methylated GGQ in the Peptidyl Transferase Center during translation termination… | x-ray diffraction | BV, DV | MG | 3 (best 0.88) |
| 6CFJ | Crystal structure of the Thermus thermophilus 70S ribosome in complex with histidyl-CAM and bound… | x-ray diffraction | 1V, 2V | MG | 2 (best 0.88) |
| 6CFK | Crystal structure of the Thermus thermophilus 70S ribosome in complex with D-histidyl-CAM and bound… | x-ray diffraction | 1V, 2V | MG | 2 (best 0.89) |
| 6CFL | Crystal structure of the Thermus thermophilus 70S ribosome in complex with lysyl-CAM and bound to… | x-ray diffraction | 1V, 2V | MG | 2 (best 0.89) |
| 6N1D | X-ray Crystal complex showing Spontaneous Ribosomal Translocation of mRNA and tRNAs into a Chimeric… | x-ray diffraction | AL21, BL21 | MG | 3 (best 0.89) |
| Q72HR2 | AlphaFold monomer V2.0 prediction for 50S ribosomal protein L21 (Q72HR2) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 12 records
Experiment against prediction
- 4ZER chain 1V against the predicted model Q72HR2: TM-score 0.98, RMSD 0.54 Å
- 6CFL chain 1V against the predicted model Q72HR2: TM-score 0.98, RMSD 0.57 Å
- 6CFK chain 1V against the predicted model Q72HR2: TM-score 0.98, RMSD 0.58 Å
- 5V8I chain 1V against the predicted model Q72HR2: TM-score 0.98, RMSD 0.57 Å
- 5J4D chain S against the predicted model Q72HR2: TM-score 0.98, RMSD 0.60 Å
- 6CFJ chain 1V against the predicted model Q72HR2: TM-score 0.97, RMSD 0.62 Å
- 6CFJ chain 2V against the predicted model Q72HR2: TM-score 0.97, RMSD 0.65 Å
- 6B4V chain S against the predicted model Q72HR2: TM-score 0.97, RMSD 0.69 Å
- 6BOK chain S against the predicted model Q72HR2: TM-score 0.97, RMSD 0.70 Å
- 6BOH chain S against the predicted model Q72HR2: TM-score 0.96, RMSD 0.74 Å
Elsewhere
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