UniProt Q70GK9
5'-fluoro-5'-deoxyadenosine synthase (Q70GK9)
5'-fluoro-5'-deoxyadenosine synthase (UniProt Q70GK9), EC 2.5.1.63: 32 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 30 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q70GK9
- Protein
- 5'-fluoro-5'-deoxyadenosine synthase
- EC
- 2.5.1.63
- Experimental structures
- 32
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 30 · 3 records with a druggable one
Structures
33 records of Q70GK9 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1RQP | Crystal structure and mechanism of a bacterial fluorinating enzyme | x-ray diffraction | A, B, C | SAM | 10 (best 0.79) |
| 1RQP | Crystal structure and mechanism of a bacterial fluorinating enzyme | x-ray diffraction | A, B, C | — | — |
| 1RQR | Crystal structure and mechanism of a bacterial fluorinating enzyme, product complex | x-ray diffraction | A, B, C | 5FD, MET | 10 (best 0.80) |
| 1RQR | Crystal structure and mechanism of a bacterial fluorinating enzyme, product complex | x-ray diffraction | A, B, C | — | — |
| 2C2W | The fluorinase from Streptomyces cattleya is also a chlorinase. Structure of… | x-ray diffraction | A, B, C | — | — |
| 2C2W | The fluorinase from streptomyces cattleya is also a chlorinase. structure of… | x-ray diffraction | A, B, C | — | — |
| 2C4T | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed… | x-ray diffraction | A, B, C | — | — |
| 2C4T | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from streptomyces cattleya complexed… | x-ray diffraction | A, B, C | — | — |
| 2C4U | Crystal structure of the apo form of the 5'-Fluoro-5'-deoxyadenosine synthase enzyme from… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2C4U | Crystal structure of the apo form of the 5'-fluoro-5'-deoxyadenosine synthase enzyme from… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2C5B | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed… | x-ray diffraction | A, B, C | — | — |
| 2C5B | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from streptomyces cattleya complexed… | x-ray diffraction | A, B, C | — | — |
| 2C5H | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed… | x-ray diffraction | A, B, C | — | — |
| 2C5H | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from streptomyces cattleya complexed… | x-ray diffraction | A, B, C | — | — |
| 2CBX | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed… | x-ray diffraction | A, B, C | — | — |
| 2CBX | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from streptomyces cattleya complexed… | x-ray diffraction | A, B, C | — | — |
| 2CC2 | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed… | x-ray diffraction | A, B, C | — | — |
| 2CC2 | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from streptomyces cattleya complexed… | x-ray diffraction | A, B, C | — | — |
| 2V7T | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase s158g mutant complexed with… | x-ray diffraction | A, B, C | — | — |
| 2V7T | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase S158G mutant complexed with… | x-ray diffraction | A, B, C | — | — |
| 2V7U | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase s158g mutant complexed with… | x-ray diffraction | A, B, C | — | — |
| 2V7U | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase S158G mutant complexed with… | x-ray diffraction | A, B, C | — | — |
| 2V7V | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from streptomyces cattleya complexed… | x-ray diffraction | A, B, C | — | — |
| 2V7V | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from streptomyces cattleya complexed… | x-ray diffraction | A, B, C | — | — |
| 2V7W | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase s158g mutant complexed with… | x-ray diffraction | A, B, C | — | — |
| 2V7W | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase S158G mutant complexed with… | x-ray diffraction | A, B, C | — | — |
| 2V7X | X-RAY CRYSTAL STRUCTURE OF 5'-FLUORODEOXYADENOSINE SYNTHASE S158A mutant FROM STREPTOMYCES CATTLEYA… | x-ray diffraction | A, B, C | — | — |
| 2V7X | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase S158A mutant from streptomyces cattleya… | x-ray diffraction | A, B, C | — | — |
| 4CQJ | Fluorinase substrate flexibility enables last step aqueous and ambient 18F fluorination of a RGD… | x-ray diffraction | A, B, C | — | — |
| 4CQJ | Fluorinase substrate flexibility enables last step aqueous and ambient 18F fluorination of a rgd… | x-ray diffraction | A, B, C | — | — |
| 5FIU | Binding and structural studies of a 5,5-difluoromethyl adenosine nucleoside with the fluorinase… | x-ray diffraction | A, B, C | Y3J | 10 (best 0.80) |
| 5FIU | Binding and structural studies of a 5,5-difluoromethyl adenosine nucleoside with the fluorinase… | x-ray diffraction | A, B, C | — | — |
| Q70GK9 | AlphaFold monomer V2.0 prediction for 5'-fluoro-5'-deoxy-adenosine synthase (Q70GK9) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1RQP chain B against the predicted model Q70GK9: TM-score 0.99, RMSD 0.46 Å
- 5FIU chain C against the predicted model Q70GK9: TM-score 0.99, RMSD 0.54 Å
- 5FIU chain C against the predicted model Q70GK9: TM-score 0.99, RMSD 0.54 Å
- 4CQJ chain A against the predicted model Q70GK9: TM-score 0.99, RMSD 0.54 Å
- 4CQJ chain A against the predicted model Q70GK9: TM-score 0.99, RMSD 0.54 Å
- 2C2W chain B against the predicted model Q70GK9: TM-score 0.99, RMSD 0.54 Å
- 2C2W chain B against the predicted model Q70GK9: TM-score 0.99, RMSD 0.54 Å
- 4CQJ chain B against the predicted model Q70GK9: TM-score 0.99, RMSD 0.55 Å
- 4CQJ chain B against the predicted model Q70GK9: TM-score 0.99, RMSD 0.55 Å
- 2CC2 chain B against the predicted model Q70GK9: TM-score 0.99, RMSD 0.55 Å
Elsewhere
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