UniProt Q70CQ3
Ubiquitin carboxyl-terminal hydrolase 30 (Q70CQ3)
Ubiquitin carboxyl-terminal hydrolase 30 (UniProt Q70CQ3), EC 3.4.19.12: 9 experimental structures on GenesisL1, 4 ligands bound, 33 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q70CQ3
- Protein
- Ubiquitin carboxyl-terminal hydrolase 30
- EC
- 3.4.19.12
- Experimental structures
- 9
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 33 · 5 records with a druggable one
Structures
9 records of Q70CQ3 in the MolNFT archive: 9 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5OHK | Crystal structure of USP30 in covalent complex with ubiquitin propargylamide (high resolution) | x-ray diffraction | A | ZN, AYE | 5 (best 0.71) |
| 5OHK | Crystal structure of USP30 in covalent complex with ubiquitin propargylamide (high resolution) | x-ray diffraction | A | ZN, AYE | — |
| 5OHN | Crystal structure of USP30 in covalent complex with ubiquitin propargylamide (low resolution) | x-ray diffraction | A, C | ZN | 9 (best 0.76) |
| 5OHN | Crystal structure of USP30 in covalent complex with ubiquitin propargylamide (low resolution) | x-ray diffraction | A, C | AYE, ZN | — |
| 5OHP | Crystal structure of USP30 (C77A) in complex with Lys6-linked diubiquitin | x-ray diffraction | A | ZN | 6 (best 0.73) |
| 5OHP | Crystal structure of USP30 (C77A) in complex with LYS6-linked diubiquitin | x-ray diffraction | A | ZN | — |
| 8D0A | Crystal structure of human USP30 in complex with a covalent inhibitor 829 and a Fab | x-ray diffraction | A | PKH, ZN | 7 (best 0.57) |
| 8D1T | Crystal structure of human USP30 in complex with a covalent inhibitor 552 and a Fab | x-ray diffraction | A | PXW, ZN | 6 (best 0.60) |
| Q70CQ3 | AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase 30 (Q70CQ3) | — | — | — |
Ligands
- ZN · Zinc ion · in 8 records
- AYE · prop-2-en-1-amine · in 3 records
- PKH · ~{N}-[(1~{R},2~{R},4~{S},7~{E})-7-[azanyl(sulfanyl)methylidene]-7$l^{4}-azabicyclo[2.2.1]heptan-2-yl]-2-chloranyl-4-(6-cyclopropylpyrazin-2-yl)benzamide · in 1 record
- PXW · (1R,2R,4S,7E)-7-[amino(sulfanyl)methylidene]-2-{[(1P)-3-chloro-3'-(1-cyanocyclopropyl)[1,1'-biphenyl]-4-carbonyl]amino}-7-azabicyclo[2.2.1]heptan-7-ium · in 1 record
Elsewhere
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