UniProt Q6ZSG1
RING finger protein 165 (Q6ZSG1)
RING finger protein 165 (UniProt Q6ZSG1), EC 2.3.2.27: 13 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q6ZSG1
- Protein
- RING finger protein 165
- EC
- 2.3.2.27
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 17 · 2 records with a druggable one
Structures
14 records of Q6ZSG1 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5D0I | Structure of RING finger protein 165 | x-ray diffraction | A, B | ZN, SO4 | — |
| 5D0I | Structure of ring finger protein 165 | x-ray diffraction | A, B | — | — |
| 5D0K | Structure of UbE2D2:RNF165:Ub complex | x-ray diffraction | C, F, I, L | ZN | 13 (best 0.67) |
| 5D0K | Structure of UBE2D2:RNF165:UB complex | x-ray diffraction | C, F, I, L | — | — |
| 5D0M | Structure of UbE2D2:RNF165:Ub complex | x-ray diffraction | C | ZN | 2 (best 0.68) |
| 5D0M | Structure of UBE2D2:RNF165:UB complex | x-ray diffraction | C | — | — |
| 5ULH | Structure of RNF165 in complex with a UbcH5b~Ub conjugate | x-ray diffraction | C | ZN | — |
| 5ULH | Structure of RNF165 in complex with a UBCH5B~UB conjugate | x-ray diffraction | C | ZN | — |
| 5ULK | Crystal Structure of RNF165 in complex with a UbcH5b~Ub conjugate | x-ray diffraction | C | ZN | 1 (best 0.31) |
| 5ULK | Crystal structure of RNF165 in complex with a UBCH5B~UB conjugate | x-ray diffraction | C | ZN | — |
| 7R70 | Crystal structure of the UBARK2C fusion protein | x-ray diffraction | A, B | ZN | — |
| 7R71 | Crystal Structure of the UbArk2C-UbcH5b~Ub complex | x-ray diffraction | A | ZN | — |
| 7R71 | Crystal structure of the UBARK2C-UBCH5B~UB complex | x-ray diffraction | A | ZN | — |
| Q6ZSG1 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase RNF165 (Q6ZSG1) | predicted | A | — | 1 (best 0.34) |
Ligands
Experiment against prediction
- 5D0M chain C against the predicted model Q6ZSG1: TM-score 0.98, RMSD 0.33 Å
- 5D0M chain C against the predicted model Q6ZSG1: TM-score 0.98, RMSD 0.33 Å
- 5D0K chain I against the predicted model Q6ZSG1: TM-score 0.97, RMSD 0.65 Å
- 5D0K chain L against the predicted model Q6ZSG1: TM-score 0.96, RMSD 0.69 Å
- 5D0K chain C against the predicted model Q6ZSG1: TM-score 0.96, RMSD 0.77 Å
- 5D0K chain C against the predicted model Q6ZSG1: TM-score 0.96, RMSD 0.77 Å
- 5D0K chain F against the predicted model Q6ZSG1: TM-score 0.96, RMSD 0.76 Å
- 5D0K chain F against the predicted model Q6ZSG1: TM-score 0.96, RMSD 0.76 Å
- 5ULK chain C against the predicted model Q6ZSG1: TM-score 0.96, RMSD 0.48 Å
- 5ULK chain C against the predicted model Q6ZSG1: TM-score 0.96, RMSD 0.48 Å
Elsewhere
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