UniProt Q6V4S5
Protein sidekick-2 (Q6V4S5)
Protein sidekick-2 (UniProt Q6V4S5): 10 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 54 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q6V4S5
- Protein
- Protein sidekick-2
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 54 · 6 records with a druggable one
Structures
11 records of Q6V4S5 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5K6X | Sidekick-2 immunoglobulin domains 1-4, crystal form 1 | x-ray diffraction | A, B | NAG, FUC, SO4 | 10 (best 0.81) |
| 5K6X | Sidekick-2 immunoglobulin domains 1-4, crystal form 1 | x-ray diffraction | A, B | NAG, FUC, SO4 | — |
| 5K6Y | Sidekick-2 immunoglobulin domains 1-4, crystal form 2 | x-ray diffraction | A, B | NAG, FUC | 9 (best 0.71) |
| 5K6Y | Sidekick-2 immunoglobulin domains 1-4, crystal form 2 | x-ray diffraction | A, B | NAG, FUC | — |
| 5K6Z | Sidekick chimera containing sidekick-2 immunoglobulin domains 1-2 and sidekick-1 immunoglobulin… | x-ray diffraction | A, B | NAG | 5 (best 0.73) |
| 5K6Z | Sidekick chimera containing sidekick-2 immunoglobulin domains 1-2 and sidekick-1 immunoglobulin… | x-ray diffraction | A, B | NAG | — |
| 5K70 | Sidekick-2 immunoglobulin domains 1-4 H18R/N22S mutant | x-ray diffraction | A, B, C, D | NAG, FUC, PO4 | 12 (best 0.74) |
| 5K70 | Sidekick-2 immunoglobulin domains 1-4 H18R/N22S mutant | x-ray diffraction | A, B, C, D | NAG, FUC, PO4 | — |
| 5XX0 | Crystal structure of the four N-terminal immunoglogulin domains of Sidekick-2 protein | x-ray diffraction | A, B | — | 6 (best 0.73) |
| 5XX0 | Crystal structure of the four N-terminal immunoglogulin domains of sidekick-2 protein | x-ray diffraction | A, B | — | — |
| Q6V4S5 | AlphaFold monomer V2.0 prediction for protein sidekick-2 (Q6V4S5) | predicted | A | — | 12 (best 0.69) |
Ligands
Experiment against prediction
- 5K70 chain D against the predicted model Q6V4S5: TM-score 0.95, RMSD 1.58 Å
- 5K70 chain D against the predicted model Q6V4S5: TM-score 0.95, RMSD 1.58 Å
- 5K6Z chain A against the predicted model Q3UH53: TM-score 0.95, RMSD 1.72 Å
- 5K6Z chain A against the predicted model Q3UH53: TM-score 0.95, RMSD 1.72 Å
- 5K70 chain C against the predicted model Q6V4S5: TM-score 0.94, RMSD 1.91 Å
- 5K70 chain C against the predicted model Q6V4S5: TM-score 0.94, RMSD 1.91 Å
- 5K70 chain A against the predicted model Q6V4S5: TM-score 0.94, RMSD 1.98 Å
- 5K70 chain A against the predicted model Q6V4S5: TM-score 0.94, RMSD 1.98 Å
- 5K70 chain B against the predicted model Q6V4S5: TM-score 0.94, RMSD 2.02 Å
- 5K70 chain B against the predicted model Q6V4S5: TM-score 0.94, RMSD 2.02 Å
Elsewhere
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