UniProt Q6FH49
NNMT protein (Q6FH49)
NNMT protein (UniProt Q6FH49): 11 experimental structures on GenesisL1, 6 ligands bound, 62 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q6FH49
- Protein
- NNMT protein
- Experimental structures
- 11
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 62 · 6 records with a druggable one
Structures
11 records of Q6FH49 in the MolNFT archive: 11 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6ORR | Co-crystal structure of human NicotinamideN-Methyltransferase (NNMT) in complex with High-Affinity… | x-ray diffraction | A, B, C, D | N37 | 9 (best 0.81) |
| 6ORR | Co-crystal structure of human nicotinamiden-methyltransferase (nnmt) in complex with high-affinity… | x-ray diffraction | A, B, C, D | N37 | — |
| 6PVE | Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with inhibitor LL319 | x-ray diffraction | A, B, C, D | OZP | 13 (best 0.82) |
| 6PVE | Structure of nicotinamide N-methyltransferase (nnmt) in complex with inhibitor LL319 | x-ray diffraction | A, B, C, D | OZP | — |
| 6PVS | Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with inhibitor LL320 | x-ray diffraction | A, B, C, D | P0V | 12 (best 0.82) |
| 6PVS | Structure of nicotinamide N-methyltransferase (nnmt) in complex with inhibitor LL320 | x-ray diffraction | A, B, C, D | P0V | — |
| 7RKK | Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with II399 (C2 space group) | x-ray diffraction | A, B | 5R4 | 6 (best 0.84) |
| 7RKK | Structure of nicotinamide N-methyltransferase (nnmt) in complex with II399 (C2 space group) | x-ray diffraction | A, B | 5R4 | — |
| 7RKL | Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with II399 (P1 space group) | x-ray diffraction | A, B, C, D | 5R4, SO4 | 12 (best 0.81) |
| 7RKL | Structure of nicotinamide N-methyltransferase (nnmt) in complex with II399 (P1 space group) | x-ray diffraction | A, B, C, D | 5R4, SO4 | — |
| 7SOK | Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with inhibitor II329 | x-ray diffraction | C, A, B, D | 9XL | 10 (best 0.82) |
Ligands
- 5R4 · 3-[3-(acetyl{[(1R,2R,3S,4R)-4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,3-dihydroxycyclopentyl]methyl}amino)prop-1-yn-1-yl]benzamide · in 4 records
- N37 · 9-{9-amino-6-[(3-carbamoylphenyl)ethynyl]-5,6,7,8,9-pentadeoxy-D-glycero-alpha-L-talo-decofuranuronosyl}-9H-purin-6-amine · in 2 records
- OZP · 9-(5-{[(3S)-3-amino-3-carboxypropyl][3-(3-carbamoylphenyl)propyl]amino}-5-deoxy-alpha-D-ribofuranosyl)-9H-purin-6-amine · in 2 records
- P0V · 9-(5-{[(3R)-3-amino-3-carboxypropyl][3-(3-carbamoylphenyl)prop-2-yn-1-yl]amino}-5-deoxy-alpha-D-lyxofuranosyl)-9H-purin-6-amine · in 2 records
- SO4 · Sulfate ion · in 2 records
- 9XL · (2S)-2-amino-4-([3-(3-carbamoylphenyl)prop-2-yn-1-yl]{[(1R,2R,3S,4R)-4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,3-dihydroxycyclopentyl]methyl}amino)butanoic acid · in 1 record
Elsewhere
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