UniProt Q67A25
S-norcoclaurine synthase (Q67A25)
S-norcoclaurine synthase (UniProt Q67A25), EC 4.2.1.78: 12 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q67A25
- Protein
- S-norcoclaurine synthase
- EC
- 4.2.1.78
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 9 · 4 records with a druggable one
Structures
13 records of Q67A25 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2VNE | The X-ray structure of Norcoclaurine synthase from Thalictrum flavum | x-ray diffraction | A, B | — | — |
| 2VNE | The X-ray structure of norcoclaurine synthase from thalictrum flavum | x-ray diffraction | A, B | — | — |
| 2VQ5 | X-ray structure of Norcoclaurine synthase from Thalictrum flavum in complex with dopamine and… | x-ray diffraction | A, B | — | — |
| 2VQ5 | X-ray structure of norcoclaurine synthase from thalictrum flavum in complex with dopamine and… | x-ray diffraction | A, B | — | — |
| 5N8Q | Structure of truncated Norcoclaurine Synthase from Thalictrum flavum | x-ray diffraction | A, B, C | — | — |
| 5N8Q | Structure of truncated norcoclaurine synthase from thalictrum flavum | x-ray diffraction | A, B, C | — | — |
| 5NON | Structure of truncated Norcoclaurine Synthase from Thalictrum flavum with product mimic | x-ray diffraction | A, B, C | 93H | 6 (best 0.73) |
| 5NON | Structure of truncated norcoclaurine synthase from thalictrum flavum with product mimic | x-ray diffraction | A, B, C | 93H | — |
| 6RP3 | Truncated Norcoclaurine synthase with reaction intermediate mimic | x-ray diffraction | A | KCZ | 1 (best 0.72) |
| 6RP3 | Truncated norcoclaurine synthase with reaction intermediate mimic | x-ray diffraction | A | KCZ | — |
| 6Z82 | Thalictrum flavumn Norcoclaurine synthase point mutant in complex with a transition state analoge | x-ray diffraction | A | QBW | 1 (best 0.70) |
| 6Z82 | Thalictrum flavumn norcoclaurine synthase point mutant in complex with a transition state analoge | x-ray diffraction | A | QBW | — |
| Q67A25 | AlphaFold monomer V2.0 prediction for S-norcoclaurine synthase (Q67A25) | predicted | A | — | 1 (best 0.76) |
Ligands
Experiment against prediction
- 5NON chain C against the predicted model Q67A25: TM-score 0.99, RMSD 0.64 Å
- 5NON chain C against the predicted model Q67A25: TM-score 0.99, RMSD 0.64 Å
- 5NON chain A against the predicted model Q67A25: TM-score 0.99, RMSD 0.56 Å
- 5NON chain A against the predicted model Q67A25: TM-score 0.99, RMSD 0.56 Å
- 2VNE chain B against the predicted model Q67A25: TM-score 0.99, RMSD 0.55 Å
- 2VNE chain B against the predicted model Q67A25: TM-score 0.99, RMSD 0.55 Å
- 2VQ5 chain B against the predicted model Q67A25: TM-score 0.99, RMSD 0.56 Å
- 2VQ5 chain B against the predicted model Q67A25: TM-score 0.99, RMSD 0.56 Å
- 5NON chain B against the predicted model Q67A25: TM-score 0.98, RMSD 0.67 Å
- 5NON chain B against the predicted model Q67A25: TM-score 0.98, RMSD 0.67 Å
Elsewhere
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