UniProt Q5W0Z9
human DHHC20 palmitoyltransferase (Q5W0Z9)
human DHHC20 palmitoyltransferase (UniProt Q5W0Z9), EC 2.3.1.-, 2.3.1.225: 8 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 30 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q5W0Z9
- Protein
- human DHHC20 palmitoyltransferase
- EC
- 2.3.1.-, 2.3.1.225
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 30 · 5 records with a druggable one
Structures
9 records of Q5W0Z9 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6BML | Structure of human DHHC20 palmitoyltransferase, irreversibly inhibited by 2-bromopalmitate | x-ray diffraction | A, B | ZN, PLM, PO4, PAP | 6 (best 0.71) |
| 6BML | Structure of human DHHC20 palmitoyltransferase, irreversibly inhibited by 2-bromopalmitate | x-ray diffraction | A, B | ZN, PLM, PO4, PAP | — |
| 6BMM | Structure of human DHHC20 palmitoyltransferase, space group P21 | x-ray diffraction | A, B | ZN, PO4, OLB, DYD | 6 (best 0.75) |
| 6BMM | Structure of human DHHC20 palmitoyltransferase, space group P21 | x-ray diffraction | A, B | ZN, PO4, OLB, DYD | — |
| 6BMN | Structure of human DHHC20 palmitoyltransferase, space group P63 | x-ray diffraction | A, B | ZN, PO4, PAP | 7 (best 0.73) |
| 6BMN | Structure of human DHHC20 palmitoyltransferase, space group P63 | x-ray diffraction | A, B | ZN, PO4, PAP | — |
| 7KHM | Crystal structure of hDHHS20 bound to palmitoyl CoA | x-ray diffraction | A, B | ZN, PKZ, PO4 | 8 (best 0.75) |
| 7KHM | Crystal structure of HDHHS20 bound to palmitoyl CoA | x-ray diffraction | A, B | ZN, PKZ, PO4 | — |
| Q5W0Z9 | AlphaFold monomer V2.0 prediction for palmitoyltransferase ZDHHC20 (Q5W0Z9) | predicted | A | — | 3 (best 0.68) |
Ligands
Experiment against prediction
- 6BMN chain A against the predicted model Q5W0Z9: TM-score 1.00, RMSD 0.45 Å
- 6BMN chain A against the predicted model Q5W0Z9: TM-score 1.00, RMSD 0.45 Å
- 6BML chain A against the predicted model Q5W0Z9: TM-score 0.99, RMSD 0.45 Å
- 6BML chain A against the predicted model Q5W0Z9: TM-score 0.99, RMSD 0.45 Å
- 6BML chain B against the predicted model Q5W0Z9: TM-score 0.99, RMSD 0.66 Å
- 6BML chain B against the predicted model Q5W0Z9: TM-score 0.99, RMSD 0.66 Å
- 6BMN chain B against the predicted model Q5W0Z9: TM-score 0.99, RMSD 0.68 Å
- 6BMN chain B against the predicted model Q5W0Z9: TM-score 0.99, RMSD 0.68 Å
- 6BMM chain B against the predicted model Q5W0Z9: TM-score 0.99, RMSD 0.59 Å
- 6BMM chain B against the predicted model Q5W0Z9: TM-score 0.99, RMSD 0.59 Å
Elsewhere
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