UniProt Q5U925

Activator of 2-hydroxyisocaproyl-CoA dehydratase (Q5U925)

Activator of 2-hydroxyisocaproyl-CoA dehydratase (UniProt Q5U925): 6 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 24 pockets. Binding sites, druggability and experiment against prediction…

UniProt: Q5U925
Protein: Activator of 2-hydroxyisocaproyl-CoA dehydratase
Experimental structures: 6
Predicted models: 1
Ligands: 7
Pockets: 24 · 4 records with a druggable one

Structures

7 records of Q5U925 in the MolNFT archive: 6 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
4EHT	Activator of the 2-Hydroxyisocaproyl-CoA dehydratase from Clostridium difficile with bound ADP	x-ray diffraction	A, B	SF4, ADP, MG, CL, NH4	4 (best 0.66)
4EHT	Activator of the 2-hydroxyisocaproyl-CoA dehydratase from clostridium difficile with bound ADP	x-ray diffraction	A, B	SF4, ADP, MG, CL, NH4	4 (best 0.66)
4EHU	Activator of the 2-Hydroxyisocaproyl-CoA Dehydratase from Clostridium difficile with bound ADPNP	x-ray diffraction	A, B	SF4, ANP, MG, NA	6 (best 0.65)
4EHU	Activator of the 2-hydroxyisocaproyl-CoA dehydratase from clostridium difficile with bound adpnp	x-ray diffraction	A, B	SF4, ANP, MG, NA	6 (best 0.65)
4EIA	Activator of the 2-Hydroxyisocaproyl-CoA Dehydratase from Clostridium difficile without nucleotide	x-ray diffraction	A	SF4	2 (best 0.38)
4EIA	Activator of the 2-hydroxyisocaproyl-CoA dehydratase from clostridium difficile without nucleotide	x-ray diffraction	A	SF4	2 (best 0.38)
Q5U925	AlphaFold monomer V2.0 prediction for 2-hydroxyisocaproyl-CoA dehydratase activator (Q5U925)	predicted	A	—	—

Ligands

SF4 · Iron/sulfur cluster · in 6 records
MG · Magnesium ion · in 4 records
ADP · Adenosine-5'-diphosphate · in 2 records
ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
CL · Chloride ion · in 2 records
NA · Sodium ion · in 2 records
NH4 · Ammonium ion · in 2 records

Experiment against prediction

4EHU chain A against the predicted model Q5U925: TM-score 0.97, RMSD 1.20 Å
4EHU chain A against the predicted model Q5U925: TM-score 0.97, RMSD 1.20 Å
4EHT chain A against the predicted model Q5U925: TM-score 0.97, RMSD 1.22 Å
4EHT chain A against the predicted model Q5U925: TM-score 0.97, RMSD 1.22 Å
4EHT chain B against the predicted model Q5U925: TM-score 0.97, RMSD 1.02 Å
4EHT chain B against the predicted model Q5U925: TM-score 0.97, RMSD 1.02 Å
4EHU chain B against the predicted model Q5U925: TM-score 0.97, RMSD 1.04 Å
4EHU chain B against the predicted model Q5U925: TM-score 0.97, RMSD 1.04 Å
4EIA chain A against the predicted model Q5U925: TM-score 0.75, RMSD 3.29 Å
4EIA chain A against the predicted model Q5U925: TM-score 0.75, RMSD 3.29 Å

Elsewhere

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.