UniProt Q5U923
beta-subunit 2-hydroxyacyl-CoA dehydratase (Q5U923)
beta-subunit 2-hydroxyacyl-CoA dehydratase (UniProt Q5U923): 6 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 89 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q5U923
- Protein
- beta-subunit 2-hydroxyacyl-CoA dehydratase
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 89 · 7 records with a druggable one
Structures
7 records of Q5U923 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3O3M | (R)-2-Hydroxyisocaproyl-CoA Dehydratase | x-ray diffraction | B, D | SF4, H2S | 16 (best 0.81) |
| 3O3M | (R)-2-hydroxyisocaproyl-CoA dehydratase | x-ray diffraction | B, D | SF4, H2S | 16 (best 0.81) |
| 3O3N | (R)-2-hydroxyisocaproyl-CoA dehydratase in complex with its substrate (R)-2-hydroxyisocaproyl-CoA | x-ray diffraction | B, D | SF4, H2S | 16 (best 0.79) |
| 3O3N | (R)-2-hydroxyisocaproyl-CoA dehydratase in complex with its substrate (R)-2-hydroxyisocaproyl-CoA | x-ray diffraction | B, D | SF4, H2S | 16 (best 0.79) |
| 3O3O | (R)-2-hydroxyisocaproyl-CoA dehydratase in complex with (R)-2-hydroxyisocaproate | x-ray diffraction | B | SF4, H2S | 10 (best 0.83) |
| 3O3O | (R)-2-hydroxyisocaproyl-CoA dehydratase in complex with (R)-2- hydroxyisocaproate | x-ray diffraction | B | SF4, H2S | 10 (best 0.83) |
| Q5U923 | AlphaFold monomer V2.0 prediction for (R)-2-hydroxyisocaproyl-CoA dehydratase beta subunit (Q5U923) | predicted | A | — | 5 (best 0.78) |
Ligands
Experiment against prediction
- 3O3M chain B against the predicted model Q5U923: TM-score 0.99, RMSD 0.55 Å
- 3O3M chain B against the predicted model Q5U923: TM-score 0.99, RMSD 0.55 Å
- 3O3N chain B against the predicted model Q5U923: TM-score 0.99, RMSD 0.55 Å
- 3O3N chain B against the predicted model Q5U923: TM-score 0.99, RMSD 0.55 Å
- 3O3M chain D against the predicted model Q5U923: TM-score 0.99, RMSD 0.56 Å
- 3O3M chain D against the predicted model Q5U923: TM-score 0.99, RMSD 0.56 Å
- 3O3O chain B against the predicted model Q5U923: TM-score 0.99, RMSD 0.81 Å
- 3O3O chain B against the predicted model Q5U923: TM-score 0.99, RMSD 0.81 Å
Elsewhere
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