UniProt Q5TCY1
Tau-tubulin kinase 1 (Q5TCY1)
Tau-tubulin kinase 1 (UniProt Q5TCY1), EC 2.7.11.1: 23 experimental structures on GenesisL1, 8 ligands bound, 13 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q5TCY1
- Protein
- Tau-tubulin kinase 1
- EC
- 2.7.11.1
- Experimental structures
- 23
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 13 · 8 records with a druggable one
Structures
23 records of Q5TCY1 in the MolNFT archive: 23 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4BTJ | TTBK1 in complex with ATP | x-ray diffraction | A, B | — | — |
| 4BTJ | TTBK1 in complex with ATP | x-ray diffraction | A, B | — | — |
| 4BTK | TTBK1 in complex with inhibitor | x-ray diffraction | A | — | — |
| 4BTK | TTBK1 in complex with inhibitor | x-ray diffraction | A | — | — |
| 4BTM | TTBK1 in complex with inhibitor | x-ray diffraction | A, B | — | — |
| 4BTM | TTBK1 in complex with inhibitor | x-ray diffraction | A, B | — | — |
| 4NFM | Human tau tubulin kinase 1 (TTBK1) | x-ray diffraction | A | — | — |
| 4NFM | Human tau tubulin kinase 1 (TTBK1) | x-ray diffraction | A | — | — |
| 4NFN | Human tau tubulin kinase 1 (TTBK1) complexed with 3-({5-[(4-amino-4-methylpiperidin-1-yl)methyl]pyrr… | x-ray diffraction | A | — | — |
| 4NFN | Human tau tubulin kinase 1 (TTBK1) complexed with 3-({5-[(4-amino-4… | x-ray diffraction | A | — | — |
| 7JXX | Structure of TTBK1 kinase domain in complex with Compound 3 | x-ray diffraction | A | VP7, NA | 1 (best 0.62) |
| 7JXX | Structure of TTBK1 kinase domain in complex with compound 3 | x-ray diffraction | A | VP7, NA | — |
| 7JXY | Structure of TTBK1 kinase domain in complex with Compound 18 | x-ray diffraction | A, B | VSY | 3 (best 0.75) |
| 7JXY | Structure of TTBK1 kinase domain in complex with compound 18 | x-ray diffraction | A, B | VSY | — |
| 7Q8V | Crystal structure of TTBK1 in complex with VNG2.73 (compound 42) | x-ray diffraction | A | PO4, 9IV | 1 (best 0.62) |
| 7Q8V | Crystal structure of TTBK1 in complex with VNG2.73 (compound 42) | x-ray diffraction | A | PO4, 9IV | — |
| 7Q8W | Crystal structure of TTBK1 in complex with VNG1.35 (compound 23) | x-ray diffraction | A | 9IO, PO4 | 1 (best 0.62) |
| 7Q8W | Crystal structure of TTBK1 in complex with VNG1.35 (compound 23) | x-ray diffraction | A | 9IO, PO4 | — |
| 7ZHN | Crystal structure of TTBK1 in complex with AMG28 | x-ray diffraction | A | PO4, VP7 | 2 (best 0.66) |
| 7ZHO | Crystal structure of TTBK1 in complex with compound 3 (7-001) | x-ray diffraction | A | PO4, IQR | 2 (best 0.64) |
| 7ZHQ | Crystal structure of TTBK1 in complex with compound 10 (7-009) | x-ray diffraction | A | PO4, IRD | 1 (best 0.66) |
| 8XPZ | The Crystal Structure of TTBK1 from Biortus. | x-ray diffraction | A | — | 2 (best 0.62) |
| Q5TCY1 | AlphaFold monomer V2.0 prediction for tau-tubulin kinase 1 (Q5TCY1) | — | — | — |
Ligands
- PO4 · Phosphate ion · in 7 records
- VP7 · 4-(2-amino-5,6,7,8-tetrahydropyrimido[4',5':3, 4]cyclohepta[1,2-b]indol-11-yl)-2-methylbut-3-yn-2-ol · in 3 records
- 9IO · ~{N}-(4-methoxyphenyl)-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine · in 2 records
- 9IV · ~{N}-[4-(2-chloranylphenoxy)phenyl]-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine · in 2 records
- NA · Sodium ion · in 2 records
- VSY · (3S)-1-[1-(2-aminopyrimidin-4-yl)-1H-pyrazolo[4,3-c]pyridin-6-yl]-3-methylpent-1-yn-3-ol · in 2 records
- IQR · 4-[3-(2-azanylpyrimidin-4-yl)-1~{H}-indol-5-yl]-2-methyl-but-3-yn-2-ol · in 1 record
- IRD · (3~{S})-1-(4-azanyl-3,5,12-triazatetracyclo[9.7.0.0^{2,7}.0^{13,18}]octadeca-1(11),2,4,6,13(18),14,16-heptaen-16-yl)-3-methyl-pent-1-yn-3-ol · in 1 record
Elsewhere
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