UniProt Q5T280
Putative methyltransferase C9orf114 (Q5T280)
Putative methyltransferase C9orf114 (UniProt Q5T280): 5 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q5T280
- Protein
- Putative methyltransferase C9orf114
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 10 · 3 records with a druggable one
Structures
6 records of Q5T280 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4RG1 | Methyltransferase domain of C9orf114 | x-ray diffraction | A, B | — | — |
| 4RG1 | Methyltransferase domain of C9ORF114 | x-ray diffraction | A, B | — | — |
| 8QSU | Bi-allelic variants of SPOUT1, a novel RNA methyltransferase, cause chromosome missegregation and a… | x-ray diffraction | A | SAH | 3 (best 0.66) |
| 8QSV | Bi-allelic variants of SPOUT1, a novel RNA methyltransferase, cause chromosome missegregation and a… | x-ray diffraction | A | SAM | 3 (best 0.65) |
| 8QSW | Bi-allelic variants of SPOUT1, a novel RNA methyltransferase, cause chromosome missegregation and a… | x-ray diffraction | A | — | 4 (best 0.59) |
| Q5T280 | AlphaFold monomer V2.0 prediction for putative methyltransferase C9ORF114 (Q5T280) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4RG1 chain B against the predicted model Q5T280: TM-score 0.99, RMSD 0.53 Å
- 4RG1 chain B against the predicted model Q5T280: TM-score 0.99, RMSD 0.53 Å
- 8QSU chain A against the predicted model Q5T280: TM-score 0.99, RMSD 0.68 Å
- 8QSV chain A against the predicted model Q5T280: TM-score 0.98, RMSD 0.91 Å
- 4RG1 chain A against the predicted model Q5T280: TM-score 0.98, RMSD 0.96 Å
- 4RG1 chain A against the predicted model Q5T280: TM-score 0.98, RMSD 0.96 Å
- 8QSW chain A against the predicted model Q5T280: TM-score 0.98, RMSD 0.98 Å
Elsewhere
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