UniProt Q5NUL3
Free fatty acid receptor 4 (Q5NUL3)
Free fatty acid receptor 4 (UniProt Q5NUL3): 3 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q5NUL3
- Protein
- Free fatty acid receptor 4
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 17 · 3 records with a druggable one
Structures
4 records of Q5NUL3 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8H4I | DHA-bound FFAR4 in complex with Gs | electron microscopy | R | HXA | 6 (best 0.82) |
| 8ID8 | Cryo-EM structure of the TUG891 bound GPR120-Gi complex | electron microscopy | R | YN9 | 5 (best 0.82) |
| 8T3O | Cryo-EM structure of the TUG-891 bound FFA4-Gq complex | electron microscopy | R | YN9, 2Y5, PLM | 6 (best 0.79) |
| Q5NUL3 | AlphaFold monomer V2.0 prediction for free fatty acid receptor 4 (Q5NUL3) | predicted | A | — | — |
Ligands
- YN9 · 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid · in 2 records
- 2Y5 · (2R)-1-{[(R)-hydroxy{[(1r,2r,3r,4r,5s,6r)-2,3,5,6-tetrahydroxy-4-(phosphonooxy) cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy) propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate · in 1 record
- HXA · Docosa-4,7,10,13,16,19-hexaenoic acid · in 1 record
- PLM · Palmitic acid · in 1 record
Experiment against prediction
- 8H4I chain R against the predicted model Q5NUL3: TM-score 0.93, RMSD 1.84 Å
- 8T3O chain R against the predicted model Q5NUL3: TM-score 0.90, RMSD 2.27 Å
- 8ID8 chain R against the predicted model Q5NUL3: TM-score 0.90, RMSD 2.35 Å
Elsewhere
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