UniProt Q5JIZ3
N(4)-bis(aminopropyl)spermidine synthase (Q5JIZ3)
N(4)-bis(aminopropyl)spermidine synthase (UniProt Q5JIZ3), EC 2.5.1.128: 8 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 38 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q5JIZ3
- Protein
- N(4)-bis(aminopropyl)spermidine synthase
- EC
- 2.5.1.128
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 38 · 4 records with a druggable one
Structures
9 records of Q5JIZ3 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5XNC | Crystal structure of the branched-chain polyamine synthase (BpsA) in complex with… | x-ray diffraction | A, B, C, D, E, F, G | MTA, N4P, FE | 20 (best 0.82) |
| 5XNC | Crystal structure of the branched-chain polyamine synthase (bpsa) in complex with… | x-ray diffraction | A, B, C, D, E, F, G | MTA, N4P, FE | — |
| 5XNF | Crystal structure of the branched-chain polyamine synthase (BpsA) from Thermococcus kodakarensis | x-ray diffraction | A, B | FE, SO4 | 6 (best 0.71) |
| 5XNF | Crystal structure of the branched-chain polyamine synthase (bpsa) from thermococcus kodakarensis | x-ray diffraction | A, B | FE, SO4 | — |
| 5XNH | Crystal structure of the branched-chain polyamine synthase (BpsA) in complex with spermidine | x-ray diffraction | A, H | FE, SPD | 6 (best 0.74) |
| 5XNH | Crystal structure of the branched-chain polyamine synthase (bpsa) in complex with spermidine | x-ray diffraction | A, H | FE, SPD | — |
| 6J26 | Crystal structure of the branched-chain polyamine synthase from Thermococcus kodakarensis (Tk-BpsA)… | x-ray diffraction | A, B | MTA, B5L, FE | 6 (best 0.81) |
| 6J26 | Crystal structure of the branched-chain polyamine synthase from thermococcus kodakarensis (tk-bpsa)… | x-ray diffraction | A, B | MTA, B5L, FE | — |
| Q5JIZ3 | AlphaFold monomer V2.0 prediction for N(4)-BIS(AMINOPROPYL)SPERMIDINE synthase (Q5JIZ3) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6J26 chain A against the predicted model Q5JIZ3: TM-score 0.98, RMSD 0.73 Å
- 6J26 chain A against the predicted model Q5JIZ3: TM-score 0.98, RMSD 0.73 Å
- 6J26 chain B against the predicted model Q5JIZ3: TM-score 0.98, RMSD 0.74 Å
- 6J26 chain B against the predicted model Q5JIZ3: TM-score 0.98, RMSD 0.74 Å
- 5XNC chain C against the predicted model Q5JIZ3: TM-score 0.98, RMSD 0.75 Å
- 5XNC chain C against the predicted model Q5JIZ3: TM-score 0.98, RMSD 0.75 Å
- 5XNC chain E against the predicted model Q5JIZ3: TM-score 0.98, RMSD 0.76 Å
- 5XNC chain E against the predicted model Q5JIZ3: TM-score 0.98, RMSD 0.76 Å
- 5XNC chain D against the predicted model Q5JIZ3: TM-score 0.98, RMSD 0.77 Å
- 5XNC chain D against the predicted model Q5JIZ3: TM-score 0.98, RMSD 0.77 Å
Elsewhere
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