UniProt Q5HII6
Methionine--tRNA ligase (Q5HII6)
Methionine--tRNA ligase (UniProt Q5HII6), EC 6.1.1.10: 16 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 23 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q5HII6
- Protein
- Methionine--tRNA ligase
- EC
- 6.1.1.10
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 23 · 8 records with a druggable one
Structures
17 records of Q5HII6 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7WPI | Methionyl-tRNA synthetase from Staphylococcus aureus complexed with a phenylbenzimidazole inhibitor | x-ray diffraction | A | 1V7 | 3 (best 0.73) |
| 7WPI | Methionyl-tRNA synthetase from staphylococcus aureus complexed with a phenylbenzimidazole inhibitor | x-ray diffraction | A | 1V7 | — |
| 7WPJ | Methionyl-tRNA synthetase from Staphylococcus aureus | x-ray diffraction | A | — | 3 (best 0.66) |
| 7WPJ | Methionyl-tRNA synthetase from staphylococcus aureus | x-ray diffraction | A | — | — |
| 7WPK | Methionyl-tRNA synthetase from Staphylococcus aureus complexed with L-Met | x-ray diffraction | A | MET | 4 (best 0.68) |
| 7WPK | Methionyl-tRNA synthetase from staphylococcus aureus complexed with L- met | x-ray diffraction | A | — | — |
| 7WPL | Methionyl-tRNA synthetase from staphylococcus aureus complexed with ATP | x-ray diffraction | A | ATP | — |
| 7WPM | Methionyl-tRNA synthetase from Staphylococcus aureus complexed with a fragment and ATP | x-ray diffraction | A | ATP, 2AQ | 3 (best 0.77) |
| 7WPM | Methionyl-tRNA synthetase from staphylococcus aureus complexed with a fragment and ATP | x-ray diffraction | A | ATP, 2AQ | — |
| 7WPN | Methionyl-tRNA synthetase from staphylococcus aureus complexed with a phenylbenzimidazole inhibitor… | x-ray diffraction | A | ATP, 29I | — |
| 7WPT | Methionyl-tRNA synthetase from Staphylococcus aureus complexed with a fragment M2-80 and ATP | x-ray diffraction | A | ATP, XM0 | 2 (best 0.69) |
| 7WPT | Methionyl-tRNA synthetase from staphylococcus aureus complexed with a fragment M2-80 and ATP | x-ray diffraction | A | ATP, XM0 | — |
| 7WPX | Methionyl-tRNA synthetase from Staphylococcus aureus complexed with a fragment and ATP | x-ray diffraction | A | ATP, 2I3 | 3 (best 0.77) |
| 7WPX | Methionyl-tRNA synthetase from staphylococcus aureus complexed with a fragment and ATP | x-ray diffraction | A | ATP, 2I3 | — |
| 7WQ0 | Methionyl-tRNA synthetase from Staphylococcus aureus complexed with a fragment and ATP | x-ray diffraction | A | ATP, TPA | 4 (best 0.81) |
| 7WQ0 | Methionyl-tRNA synthetase from staphylococcus aureus complexed with a fragment and ATP | x-ray diffraction | A | ATP, TPA | — |
| Q5HII6 | AlphaFold monomer V2.0 prediction for methionine--tRNA ligase (Q5HII6) | predicted | A | — | 1 (best 0.77) |
Ligands
- ATP · Adenosine-5'-triphosphate · in 10 records
- 1V7 · 2-(4-bromanyl-3-oxidanyl-phenyl)-1-[(1R)-2-[2-(2-tert-butylphenoxy)ethanoylamino]-1-(3,4-dimethoxyphenyl) ethyl]-N-methyl-benzimidazole-5-carboxamide · in 2 records
- 2AQ · Quinolin-2-amine · in 2 records
- 2I3 · 6-chloranylimidazo[2,1-b][1,3]thiazole · in 2 records
- TPA · Trans-2-phenylcyclopropylamine · in 2 records
- XM0 · Indan-2-amine · in 2 records
- 29I · (phenylmethyl) N-[(2R)-2-[2-(4-bromanyl-3-oxidanyl-phenyl)-5-(methylcarbamoyl)benzimidazol-1-yl]-2-(3,4-dimethoxyphenyl)ethyl]carbamate · in 1 record
- MET · Methionine · in 1 record
Experiment against prediction
- 7WPN chain A against the predicted model Q5HII6: TM-score 0.99, RMSD 0.66 Å
- 7WPM chain A against the predicted model Q5HII6: TM-score 0.99, RMSD 0.86 Å
- 7WPM chain A against the predicted model Q5HII6: TM-score 0.99, RMSD 0.86 Å
- 7WPT chain A against the predicted model Q5HII6: TM-score 0.99, RMSD 0.84 Å
- 7WPT chain A against the predicted model Q5HII6: TM-score 0.99, RMSD 0.84 Å
- 7WPI chain A against the predicted model Q5HII6: TM-score 0.99, RMSD 0.92 Å
- 7WPI chain A against the predicted model Q5HII6: TM-score 0.99, RMSD 0.92 Å
- 7WPJ chain A against the predicted model Q5HII6: TM-score 0.97, RMSD 1.48 Å
- 7WPJ chain A against the predicted model Q5HII6: TM-score 0.97, RMSD 1.48 Å
- 7WPK chain A against the predicted model Q5HII6: TM-score 0.97, RMSD 1.47 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.