UniProt Q5C9L7
(S)-norcoclaurine 6-O-methyltransferase (Q5C9L7)
(S)-norcoclaurine 6-O-methyltransferase (UniProt Q5C9L7), EC 2.1.1.128: 8 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 3 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q5C9L7
- Protein
- (S)-norcoclaurine 6-O-methyltransferase
- EC
- 2.1.1.128
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 3 · 3 records with a druggable one
Structures
9 records of Q5C9L7 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5ICC | Crystal structure of (S)-norcoclaurine 6-O-methyltransferase with S-adenosyl-L-homocysteine | x-ray diffraction | A | SAH, K, NA | 1 (best 0.80) |
| 5ICC | Crystal structure of (S)-norcoclaurine 6-O-methyltransferase with S- adenosyl-L-homocysteine | x-ray diffraction | A | — | — |
| 5ICE | Crystal structure of (S)-norcoclaurine 6-O-methyltransferase with S-adenosyl-L-homocysteine and… | x-ray diffraction | A | SAH, 2H4, K | 1 (best 0.80) |
| 5ICE | Crystal structure of (S)-norcoclaurine 6-O-methyltransferase with S- adenosyl-L-homocysteine and… | x-ray diffraction | A | — | — |
| 5ICF | Crystal structure of (S)-norcoclaurine 6-O-methyltransferase with S-adenosyl-L-homocysteine and… | x-ray diffraction | A | SAH, SAU, K, NA | 1 (best 0.81) |
| 5ICF | Crystal structure of (S)-norcoclaurine 6-O-methyltransferase with S- adenosyl-L-homocysteine and… | x-ray diffraction | A | — | — |
| 5ICG | Crystal structure of apo (S)-norcoclaurine 6-O-methyltransferase | x-ray diffraction | A | K | — |
| 5ICG | Crystal structure of apo (S)-norcoclaurine 6-O-methyltransferase | x-ray diffraction | A | — | — |
| Q5C9L7 | AlphaFold monomer V2.0 prediction for (rs)-norcoclaurine 6-O-methyltransferase (Q5C9L7) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5ICE chain A against the predicted model Q5C9L7: TM-score 0.99, RMSD 0.25 Å
- 5ICE chain A against the predicted model Q5C9L7: TM-score 0.99, RMSD 0.25 Å
- 5ICF chain A against the predicted model Q5C9L7: TM-score 0.99, RMSD 0.25 Å
- 5ICF chain A against the predicted model Q5C9L7: TM-score 0.99, RMSD 0.25 Å
- 5ICC chain A against the predicted model Q5C9L7: TM-score 0.99, RMSD 0.32 Å
- 5ICC chain A against the predicted model Q5C9L7: TM-score 0.99, RMSD 0.32 Å
- 5ICG chain A against the predicted model Q5C9L7: TM-score 0.85, RMSD 3.00 Å
- 5ICG chain A against the predicted model Q5C9L7: TM-score 0.85, RMSD 3.00 Å
Elsewhere
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