UniProt Q59H18
Serine/threonine-protein kinase TNNI3K (Q59H18)
Serine/threonine-protein kinase TNNI3K (UniProt Q59H18), EC 2.7.11.1: 10 experimental structures on GenesisL1, 3 ligands bound, 11 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q59H18
- Protein
- Serine/threonine-protein kinase TNNI3K
- EC
- 2.7.11.1
- Experimental structures
- 10
- Predicted models
- 0
- Ligands
- 3
- Pockets
- 11 · 1 record with a druggable one
Structures
10 records of Q59H18 in the MolNFT archive: 10 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4YFF | TNNI3K complexed with inhibitor 2 | x-ray diffraction | A, B, C, D | — | — |
| 4YFF | TNNI3K complexed with inhibitor 2 | x-ray diffraction | A, B, C, D | — | — |
| 4YFI | TNNI3K complexed with inhibitor 1 | x-ray diffraction | A, B, C, D | — | — |
| 4YFI | TNNI3K complexed with inhibitor 1 | x-ray diffraction | A, B, C, D | — | — |
| 6B5J | TNNI3K complexed with a 4,6-diaminopyrimidine | x-ray diffraction | A, B, C, D | CV4 | — |
| 7MGJ | TNNI3K complexed with N-methyl-4-(4-(3-(3-(trifluoromethyl) phenyl) ureido) phenoxy)picolinamide | x-ray diffraction | A, B, C, D | ZFS | 11 (best 0.82) |
| 7MGJ | TNNI3K complexed with N-methyl-4-(4-(3-(3-(trifluoromethyl) phenyl) ureido) PHENOXY)PICOLINAMIDE | x-ray diffraction | A, B, C, D | ZFS | — |
| 7MGK | TNNI3K complexed with 1-(3,5-dichloro-4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)-3-(3-(trifluorom… | x-ray diffraction | A, B, C, D | ZGD | — |
| 7MGK | TNNI3K complexed with 1-(3,5-dichloro-4-((6-(METHYLAMINO)PYRIMIDIN-4… | x-ray diffraction | A, B, C, D | ZGD | — |
| Q59H18 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase TNNI3K (Q59H18) | — | — | — |
Ligands
- ZFS · N-methyl-4-[4-({[3-(trifluoromethyl) phenyl]carbamoyl}amino)phenoxy]pyridine-2-carboxamide · in 2 records
- ZGD · N-(3,5-dichloro-4-{[6-(methylamino)pyrimidin-4-yl]oxy}phenyl)-N'-[3-(trifluoromethyl)phenyl]urea · in 2 records
- CV4 · N-methyl-3-[(6-{[4-(trifluoromethyl) phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamide · in 1 record
Elsewhere
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