UniProt Q543K3

Prostaglandin-endoperoxide synthase 2 (Q543K3)

Prostaglandin-endoperoxide synthase 2 (UniProt Q543K3), EC 1.14.99.1: 4 experimental structures on GenesisL1, 5 ligands bound, 60 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.

UniProt: Q543K3
Protein: Prostaglandin-endoperoxide synthase 2
EC: 1.14.99.1
Experimental structures: 4
Predicted models: 0
Ligands: 5
Pockets: 60 · 4 records with a druggable one

Structures

4 records of Q543K3 in the MolNFT archive: 4 experimental, 0 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
3NT1	High resolution structure of naproxen:COX-2 complex.	x-ray diffraction	A, B	NAG, NPS, HEM, CL	10 (best 0.81)
3NT1	High resolution structure of NAPROXEN:COX-2 complex.	x-ray diffraction	A, B	NAG, NPS, HEM, CL	10 (best 0.81)
3NTB	Structure of 6-methylthio naproxen analog bound to mCOX-2.	x-ray diffraction	A, B, C, D	NAG, HEM, T1N	20 (best 0.84)
3NTB	Structure of 6-methylthio naproxen analog bound to mcox-2.	x-ray diffraction	A, B, C, D	NAG, HEM, T1N	20 (best 0.84)

Ligands

HEM · Protoporphyrin IX containing Fe · in 4 records
NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
CL · Chloride ion · in 2 records
NPS · (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid · in 2 records
T1N · (2S)-2-[6-(methylsulfanyl)naphthalen-2-yl]propanoic acid · in 2 records

Elsewhere

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