UniProt Q53GS9
Ubiquitin carboxyl-terminal hydrolase 39 (Q53GS9)
Ubiquitin carboxyl-terminal hydrolase 39 (UniProt Q53GS9), EC 3.4.19.12: 23 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 43 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q53GS9
- Protein
- Ubiquitin carboxyl-terminal hydrolase 39
- EC
- 3.4.19.12
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 43 · 18 records with a druggable one
Structures
24 records of Q53GS9 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3JCR | 3D structure determination of the human*U4/U6.U5* tri-snRNP complex | electron microscopy | V | — | — |
| 3JCR | 3D structure determination of the HUMAN*U4/U6.U5* tri-snrnp complex | electron microscopy | V | — | — |
| 6AH0 | The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex) | electron microscopy | W | — | 1 (best 0.72) |
| 6AH0 | The cryo-EM structure of the precusor of human pre-catalytic spliceosome (pre-B complex) | electron microscopy | W | — | 1 (best 0.72) |
| 6QW6 | Structure of the human U5.U4/U6 tri-snRNP at 2.9A resolution. | electron microscopy | U | ZN | 3 (best 0.82) |
| 6QX9 | Structure of a human fully-assembled precatalytic spliceosome (pre-B complex). | electron microscopy | U | ZN | 1 (best 0.86) |
| 8H6E | Cryo-EM structure of human exon-defined spliceosome in the late pre-B state. | electron microscopy | 4T | ZN | 3 (best 0.80) |
| 8H6J | Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state. | electron microscopy | 4T | ZN | 2 (best 0.79) |
| 8QOZ | Cryo-EM Structure of Pre-B+5'ss+ATPgammaS Complex (core part) | electron microscopy | U | — | 2 (best 0.78) |
| 8QP8 | Cryo-EM Structure of Pre-B Complex (core part) | electron microscopy | U | — | 4 (best 0.83) |
| 8QP9 | Cryo-EM Structure of Pre-B+AMPPNP Complex (core part) | electron microscopy | U | — | 2 (best 0.81) |
| 8QPA | Cryo-EM Structure of Pre-B+5'ssLNG Complex (core part) | electron microscopy | U | — | 3 (best 0.80) |
| 8QPB | Cryo-EM Structure of Pre-B+ATP Complex (core part) | electron microscopy | U | — | 3 (best 0.83) |
| 8QPE | Cryo-EM Structure of Pre-B-like Complex (core part) | electron microscopy | U | — | 2 (best 0.79) |
| 8QPK | Cryo-EM Structure of Pre-B+5'ss Complex (core part) | electron microscopy | U | — | 2 (best 0.83) |
| 8QXD | Cryo-EM structure of the cross-exon pre-B complex | electron microscopy | U | — | 1 (best 0.81) |
| 8QZS | Cryo-EM structure of the cross-exon B-like complex | electron microscopy | U | — | — |
| 8R08 | Cryo-EM structure of the cross-exon pre-B+AMPPNP complex | electron microscopy | U | — | — |
| 8R09 | Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complex | electron microscopy | U | — | 1 (best 0.83) |
| 8R0A | Cryo-EM structure of the cross-exon pre-B+5'ss complex | electron microscopy | U | — | 2 (best 0.82) |
| 8R0B | Cryo-EM structure of the cross-exon pre-B+ATP complex | electron microscopy | U | — | — |
| 8RM5 | Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complex | electron microscopy | U | — | 2 (best 0.86) |
| 8Y6O | Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U11 and tri-snRNP… | electron microscopy | U | ZN | 2 (best 0.80) |
| Q53GS9 | AlphaFold monomer V2.0 prediction for U4/U6.U5 tri-snrnp-associated protein 2 (Q53GS9) | predicted | A | — | 6 (best 0.41) |
Ligands
- ZN · Zinc ion · in 5 records
Experiment against prediction
- 8QZS chain U against the predicted model Q53GS9: TM-score 0.98, RMSD 1.32 Å
- 8QPE chain U against the predicted model Q53GS9: TM-score 0.98, RMSD 1.32 Å
- 8R09 chain U against the predicted model Q53GS9: TM-score 0.98, RMSD 1.39 Å
- 8QOZ chain U against the predicted model Q53GS9: TM-score 0.98, RMSD 1.39 Å
- 8R0B chain U against the predicted model Q53GS9: TM-score 0.97, RMSD 1.45 Å
- 8QPB chain U against the predicted model Q53GS9: TM-score 0.97, RMSD 1.45 Å
- 8QPA chain U against the predicted model Q53GS9: TM-score 0.97, RMSD 1.43 Å
- 8RM5 chain U against the predicted model Q53GS9: TM-score 0.97, RMSD 1.45 Å
- 8Y6O chain U against the predicted model Q53GS9: TM-score 0.96, RMSD 1.87 Å
- 8QP8 chain U against the predicted model Q53GS9: TM-score 0.96, RMSD 1.87 Å
Elsewhere
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